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Mitochondria and cell death regulation following toxic injury

Dr L. Miguel Martins

We are investigating the cellular and molecular mechanisms that mitochondria use, as signaling hubs, for coping with toxic insults.  


We are a cell biology-based research group that aims to provide detailed, applicable, mechanistic toxicology, to identify the molecular initiating events and downstream toxicity pathways, associated with mitochondrial damage, that are disease relevant. To achieve our goals, we combine a series of approaches, including data analysis using computational tools, cultured cells and Drosophila as an in vivo model system.

We have diverse range of experitise, including genetics, computational biology, biochemistry and cell culture. This enables students to pursue multidisciplinary research. The influence and reach of our research is tracked by Altmetric here.


Key publications

Popovic, R, Mukherjee, A, Santos Leal, N, Morris, L, Yu, Y, Loh, SHY, Martins LM. Blocking dPerk in the intestine suppresses neurodegeneration in a Drosophila model of Parkinson’s disease. Cell Death & Disease 14, 206-215 (2023).

Travaglio, M, Michopoulos, F, Yu, Y, Popovic, R, Foster, E, Coen, M, Martins, LM. Increased cysteine metabolism in PINK1 models of Parkinson’s disease. Dis Model Mech 16, (2023).

Fedele G, Loh SHY, Celardo I, Santos Leal N, Lehmann S, Costa AC and Martins LM. Suppression of intestinal dysfunction in a Drosophila model of Parkinson's disease is neuroprotective. Nature Aging, 2, 317-331. (2022).

Yu Y, Fedele G, Celardo I, Loh SHY and Martins LM. Parp mutations protect from mitochondrial toxicity in Alzheimer's disease. Cell Death & Disease 12 (7):651. (2021).

Popovic R, Celardo I, Yu Y, Costa AC, Loh SHY and Martins LM. Combined transcriptomic and proteomic analysis of Perk toxicity pathways. Int J Mol Sci; 22(9):4598. (2021).

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Video abstracts