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Understanding and mediating the toxicity of CAR-T cell therapy

Dr Mike Chapman

CAR-T cell therapy is a revolutionary new cancer treatment that involves engineering a patient’s immune cells to help them attack the tumour more effectively. They are highly effective for certain types of cancer, but their use is complicated by potentially life-threatening toxicity. It is not clear why side-effects are severe in some patients and mild or non-existent in others, although it likely relates to differences in immune systems between individuals. We are using new technologies to help us better understand the immune system and to investigate how and why toxicity develops. We will use this knowledge to design interventions that make CAR-T therapy safer and more widely available.