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Tractor spraying pesticides on crops.

Pesticides and other common chemical pollutants are toxic to our ‘good’ gut bacteria

24 November 2025

Researchers in the Patil Lab have used a lab-based screening to identify over 150 common industrial chemicals, from pesticides to flame retardants, that have a toxic effect on bacteria found in the healthy human gut microbiome. We are exposed to many different chemicals in our modern world including pesticides and...

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Unit comes together for Science Day 2025

20 November 2025

Each year MRC Toxicology Unit group leaders, research staff, students and support staff take part in our annual Science Day to celebrate science and achievements over the past year. This year we were based in the beautiful Møller Institute overlooking Churchill College grounds. Eric-Miska.jpg After excellent breakfast...

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UK wide initiative to phase out animal testing

17 November 2025

The MRC Toxicology Unit is part of a £15.9 million initiative from the Medical Research Council (MRC), Innovate UK and the Wellcome Trust to advance promising ‘human in vitro models’. This sits alongside new UK government strategy to reduce animal testing, speeding up plans to phase out the use of animals in science...

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Ambitious new project to transform human disease modelling for cancer

10 November 2025

The MRC Toxicology Unit are joining an interdisciplinary team on a major new initiative that aims to redefine human-based research models for greater understanding of disease and the acceleration of new medicines. The joint £15.9 million investment by the UKRI Medical Research Council (MRC), Wellcome and UKRI Innovate UK...

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New academic-industry partnership to uncover the safety of antisense oligonucleotide therapeutics

7 November 2025

The MRC Toxicology Unit and Department of Biochemistry at the University of Cambridge, AstraZeneca, Cancer Research UK Scotland Institute, and the Mary Lyon Centre at MRC Harwell have been awarded a £3.4 million Medical Research Council Prosperity Partnership grant to fund research into understanding the early safety...

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Tiago Marques-Pedro co-chairs symposium on the Cellular and Molecular Mechanisms of Toxicity

28 October 2025

Tiago Marques-Pedro is a PhD student in the MacFarlane lab who studies mitochondrial toxicity. Tiago had the opportunity to organise and co-chair a Gordon Research Symposium. These symposiums, held the day before the main Gordon Research Conference on a particular topic, give early career researchers the chance to present...

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Unit takes part in Big Biology Day 2025

17 October 2025

Researchers from the Unit brought activities about Nucleic Acid Therapies to the Big Biology Day at Hills Road Sixth Form College on 11th October. Cambridge Biologists have been running the Big Biology Day at Hills Road Sixth Form since 2012 and its now one of the largest events of its kind in the UK! This event combines...

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MRC Toxicology Unit takes part in the Chariots of Fire race.

22 September 2025

The Chariots of Fire race is a relay race for charity that takes a scenic route through some of Cambridge's best known colleges. This year MRC Toxicology Unit members along with those from the Pharmacology Department and Gurdon Institute entered two teams, the Nucleostrides and Toxicology RuNAs. They joined around 300...

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An interview with MPhil Student Anfas Muhammed

9 September 2025

We asked Sawarkar Lab student Anfas about his research at the Tox Unit, why he chose to study an MPhil and what he likes to do when he's not in the lab. anfas_lab_with_coat.jpg What is your research about? When cells in our body encounter extreme heat, the bonds within proteins break, causing them to misfold. Misfolded...

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Niall Buckley receives Outstanding Poster prize at the Gordon Research Conference on the Molecular and Cellular Mechanisms of Toxicity

3 September 2025

Niall Buckley recently attended this year's Gordon Research Conference (GRC) on the Molecular and Cellular Mechanisms of Toxicity in New Hampshire thanks to a travel grant from the EUROTOX Congress. Niall, a postdoc in the MacFarlane lab and AstraZeneca Hepatic Safety Team, presented his work on how CDK9 inhibitors can...

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