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A tale of two strands: how DNA strand asymmetry affects damage, repair and mutation rates

12 June 2024

From snowflakes and sunflowers, to butterflies and humans, symmetry is abundant throughout nature . There is also an elegant symmetry to the double helix structure of DNA – the blueprint of life. Yet, many of the DNA’s functions are asymmetrical: only one strand is needed for certain cellular processes, and some key...

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New mouse model allows researchers to track immune cell behaviour during an immune response

24 May 2024

Researchers at the MRC Toxicology Unit have developed a new mouse model for tracking the behaviour of immune cells once an immune response is triggered. This could help scientists to understand how our immune system responds to different insults in more detail to develop new and improved immune therapies. Our body triggers...

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UK proteostasis community comes together for a successful inaugural event

21 May 2024

The conference marked the inaugural event of the UK Proteostasis Network , an initiative launched by the Babraham Institute and shaped by Network Coordinators: Ritwick Sawarkar from the MRC Toxicology Unit, Della David and Oliver Florey at the Babraham Institute, and Laura Itzhaki at the University of Cambridge.

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Computational approach to minimise off-target toxicity of CAR T-cell therapy targeting myeloma

2 May 2024

Multiple myeloma is a type of bone marrow cancer which impacts a type of white blood cell called plasma cells, which are essential for the production of antibodies. Myeloma remains incurable but a treatment called CAR-T cell therapy - a type of cancer immunotherapy - could be a promising new avenue for treatment, if...

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Toxicology Unit returns to Cambridge Festival

27 March 2024

Researchers from the MRC Toxicology Unit were involved in the Cambridge Festival 2024 last weekend to engage families with our research. The Cambridge Festival is an annual event coordinated by the University of Cambridge’s Public Engagement team. It is a multi-disciplinary festival with a mixture of online, on-demand and...

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Tox student receives 2024 Mary Amdur Student Award

14 March 2024

David O'Loughlin, PhD student in the MacFarlane lab at the MRC Toxicology Unit, has been awarded the 2024 Mary Amdur Student Award by the Society of Toxicology (SOT) at their Annual Meeting in Salt Lake City, Utah. The prize, named in honour of a pioneer in air pollution toxicology who overcame gender, political and...

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Gut microbiome remains stable after COVID-19 vaccination

5 March 2024

Our gut microbiome is home to a diverse mix of microorganisms that are delicately balanced to preserve many aspects of our health including digestion, immunity and even our mental wellbeing. There are known factors that can impact our microscopic companions such as diet, lifestyle, antibiotic use and environmental...

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Unit joins Norwich Science Festival for the first time

4 March 2024

Researchers from the Unit participated in this year's Norwich Science Festival on 24th February. It was the first time that the Unit has taken part in this event sharing our research to a wider audience. We set up our temporary tattoo parlour in The Forum in Norwich as part of our Tattoo My Science activity. We chatted to...

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Unit researchers Talking Together with the local community

26 January 2024

Towards the end of 2023, six of our researchers took part in the Talking Together programme hosted by Cambridgeshire Older People's Enterprise (COPE). Talking Together is a unique initiative that was started during the pandemic to combat isolation in the local community by bringing older adults together for stimulating...

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Researchers uncover an unexpected job for the ancient family of chaperone proteins

23 January 2024

We all go through times when we are not on track, feeling a little blue and out of our usual form. These are the times when we need a little warmth from those close to us – some extra support, a helping hand. The same goes for the proteins in our cells. Proteins are the workhorses in our cells and have numerous tasks to...

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