skip to content

MRC Toxicology Unit

 

RNA-seq and translational profiling by microarray produce lists of mRNA whose translation is regulated in unison.   We have developed many approaches (using online tools and databases, and custom scripts) to look at the sequence/structure content of these mRNA to try and determine how this control is exerted.   Such analyses look at uORFs, predicted miRNA target sites, potential IRESs, predicted secondary structure, etc., as well as looking for novel motifs.