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Miguel Martins is MRC Investigator for the Mitochondria and cell death regulation following toxic injury Programme



Miguel obtained his PhD in Molecular Medicine from the University of Porto, Portugal, while working at the Johns Hopkins School of Medicine (USA) and the University of Edinburgh (Scotland) on cell death mechanisms with Prof. William C. Earnshaw. He then moved to the Imperial Cancer Research Fund laboratories (now CRUK) to work on cellular signalling with Dr Julian Downward.  Miguel was appointed to his first independent position as a Programme Leader with the MRC Toxicology Unit in 2003.


Research Interests:

The aim of Miguel’s research programme is understanding the cellular and molecular mechanisms that mitochondria use, as signaling hubs, for coping with toxic insults.  We aim to manipulate these signaling mechanisms to protect tissues such as heart, liver and the brain from toxicity following exposure and in disease conditions.  Thus, this is a cell biology-based programme that aims to provide detailed, applicable, mechanistic toxicology, to identify the molecular initiating events and downstream toxicity pathways, associated with loss of mitochondrial function, that are disease relevant.



Key publications: 

Fedele G, Loh SHY, Celardo I, Santos Leal N, Lehmann S, Costa AC and Martins LM. Suppression of intestinal dysfunction in a Drosophila model of Parkinson's disease is neuroprotectiveNature Aging, 2, 317-331. (2022).

Santos Leal N, Yu Y, Chen Y, Fedel G and Martins LM. Paracetemol is associated with a lower risk of COVID-19 infection and decreased ACE2 protein expression: a retrospective analysisCOVID1(1), 218-229. (2021).

Yu Y, Fedele G, Celardo I, Loh SHY and Martins LM. Parp mutations protect from mitochondrial toxicity in Alzheimer's diseaseCell Death Dis; 12(7):651. (2021).

Popovic R, Celardo I, Yu Y, Costa AC, Loh SHY and Martins LM. Combined transcriptomic and proteomic analysis of Perk toxicity pathwaysInt J Mol Sci; 22(9):4598. (2021).

Santos Leal N and Martins LM. Mind the gap: mitochondria and the endoplasmic reticulum in neurodegenerative diseasesBiomedicines; 23(9):227. (2021).

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MRC Investigator

Contact Details

MRC Toxicology Unit
Gleeson Building
Tennis Court Road


Telephone and Email