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Wiktoria completed her bachelor’s degree in Biological Sciences with a Year in Industry at the University of Leeds. She has now joined the Chapman group as a PhD student at the MRC Toxicology Unit, where her research focuses on understanding and mediating the toxicity of CAR-T cell therapy.

Research Interests:

Chimeric antigen receptors (CARs) are genetically engineered recombinant receptors that can be permanently grafted onto T cells and grant them with antibody-type specificity to a desired target. CAR-T cells designed to bind to tumour-associated antigens can be effectively activated and show direct cytolytic activity towards malignant cells.
Immunotherapy has demonstrated great potential in cancer treatment of patients with B cell malignancies nevertheless, targeting solid tumours has not been as successful with many challenges that limit the therapeutic efficacy of CAR- T cells. Another major concern is manifestation of severe clinical toxicities in patients that receive CAR-T therapy which can often be life-threatening. Current understanding and research into CAR-T cell associated toxicities is limited and further research is required to improve the efficacy and safety of CAR-T cell therapy.



Key publications: 

Parol W, Anderson GSF and Chapman MA. CAR-T cell therapies for cancer: what novel technologies are being developed for toxicity data? Expert Opinion on Drug Metabolism and Toxicology; 18 (4), 241-244. (2022).

PhD Student

Contact Details

MRC Toxicology Unit
Gleeson Building
Tennis Court Road


Telephone and Email