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I studied Biology at the University of Seville and did a PhD in the laboratory of Felipe Cortés-Ledesma focused on DNA-damage repair and the role of human DNA topoisomerase II in regulating transcription. Then, I complemented my wet-lab expertise with some computational training. I am passionate about how the stored information in DNA is properly decoded by the transcriptional machinery. Thus, in 2021, I joined the group of Ritwick Sawarkar to keep understanding the mechanisms underlying transcription regulation, combining experimental approaches with genome-wide data analysis and Machine Learning techniques.


Research interests:

My main interest is understanding how a cell controls which genes are expressed.




Key publications: 

1) Topoisomerase IIα represses transcription by enforcing promoter-proximal pausing. Herrero-Ruiz A, Martínez-García PM, Terrón-Bautista J, Millán-Zambrano G, Lieberman JA, Jimeno-González S, Cortés-Ledesma F, Cell Reports. 35(2):108977 (2021). doi: 10.1016/j.celrep.2021.108977.

2) RanBP2-Mediated SUMOylation Promotes Human DNA Polymerase Lambda Nuclear Localization and DNA Repair. Moreno-Oñate M, Herrero-Ruiz AM, García-Dominguez M, Cortés-Ledesma F, Ruiz JF. Journal of Molecular Biology. 432(13):3965-3979 (2020). doi:10.1016/j.jmb.2020.03.020

3) ZATT (ZNF451)-mediated resolution of topoisomerase 2 DNA-protein cross-links. Schellenberg MJ, Lieberman JA, Herrero-Ruiz A, Butler LR, Williams JG, Muñoz-Cabello AM, Mueller GA, London RE, Cortés-Ledesma F, Williams RS. Science. 357(6358):1412-1416. (2017). doi:10.1126/science.aam6468

EMBO Postdoctoral Fellow

Contact Details

MRC Toxicology Unit
Gleeson Building
Tennis Court Road


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