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Biography:

Mathew obtained a PhD in Genetics from Cardiff University working on dosage modifications of an imprinted gene, Cdkn1c.  He then moved to London to work with Dame Professor Amanda Fisher in the MRC London Institute of Medical Sciences (LMS), where he also held a Junior Research Fellowship. During this time, he worked to develop novel models for studying epigenetics longitudinally, including establishing a number of transgenic mouse lines that enable non-invasive reporter imaging. Matthew is currently a Principal Toxicologist at UK Health Security Agency.

 

Research Interests:

Matthew is interested in Developmental and Reproductive Toxicology (DART), using in vitro models of development and the germline to assess epigenetic changes across one and two generations. He collaborates with industrial and academic partners, applying an array of molecular biology techniques to answer key mechanistic questions.

 

Publications

Key publications: 

Van de Pette M, Dimond A, Galvão AM, Millership SJ, To W, Prodani C, McNamara G, Bruno L, Sardini A, Webster Z, McGinty J, French PMW, Uren AG, Castillo-Fernandez J, Watkinson W, Ferguson-Smith AC, Merkenschlager M, John RM, Kelsey G and Fisher AG. Epigenetic changes induced by in utero dietary challenge result in phenotypic variability in successive generations of miceNature Communications; 13, 2464. (2022).

Van de Pette M, Abbas A, Feytout A, McNamara G, Bruno L, To WK, Dimond A, Sardini A, Webster Z, McGinty J, Paul EJ, Ungless MA, French PMW, Withers DJ, Uren A, Ferguson-Smith AC, Merkenschlager M, John RM and Fisher AG. Visualizing changes in Cdkn1c expression links early-life adversity to imprint mis-regulation in adultsCell Reports; 18 (5), 1090-1099. (2017).

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Previous Member

Contact Details

MRC Toxicology Unit
Gleeson Building
Tennis Court Road
Cambridge

CB2 1QR

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