Researchers from the Willis and Thaventhiran labs have discovered that misreading of therapeutic mRNAs by the cell’s decoding machinery can cause an unintended immune response in the body. They have identified the sequence within the mRNA that causes this to occur and found a way to prevent ‘off-target’ immune responses to...

You might imagine the cells in your body as quite static. In reality, they are hives of activity and contain cocktails of different molecules. Just like us, these different molecules in our cells all have a job. Just like us, those jobs span a wide range of roles and take place in designated spaces – instead of offices or...

Researchers from the MRC Toxicology Unit, in collaboration with the MRC Mitochondrial Biology Unit in Cambridge, have uncovered why individuals who are prescribed some antipsychotic drugs can develop movement disorders. How these side-effects might develop was not clear – until now - and it is all linked to damage to the...

The work of the Patil lab is featured in this story by the University of Cambridge. It explores how Cambridge scientists are trying to get a grasp on the basic rules these bacteria play by, in the hope of understanding not only what’s going on in there, but how we might be able to use our microbiome to our advantage.

When you think of traffic pollution, what comes to mind? Exhaust fumes? What about miniscule pieces of tyre rubber floating around in the atmosphere? Tyre wear particles make up a significant portion of air pollution in UK cities and is only projected to increase over the next decade. In fact, it is estimated that about 1...

Cancer is something that has impacted all of us either directly or indirectly and is a leading cause of death globally. As a result, there is an urgent and ongoing need to discover and develop new treatments to tackle this disease more efficiently. Interestingly, most of the small-molecule drugs that have been approved as...

Researchers from the MRC Toxicology Unit have identified a signature in the blood that could help predict how well an individual will respond to vaccines. The discovery, published today in the journal Nature Communications, may explain why, even among vulnerable patient groups, some individuals have better responses to...

The protection offered by COVID-19 vaccination declines more rapidly in people with severe obesity compared to those with normal weight, researchers from the MRC Toxicology Unit and collaborators within the Universities of Cambridge and Edinburgh have found. The study suggests that people with obesity are likely to need...

Cross-feeding, or the exchange of nutrients between organisms, is fundamental to the diversity and function of microbial communities. However, pinpointing the corresponding donors and receivers to understand more about this nutrient exchange is challenging as amino acids, nucleotides and more are universal across all...

Parkinson’s disease is a complex neurodegenerative disorder, and currently there is no cure. With 1 in 37 people alive today in the UK predicted to be diagnosed with Parkinson’s in their lifetime, finding new ways to diagnose earlier and delay the progression of the disease is urgently needed. Although most cases of...