Researchers from the Willis and Thaventhiran labs have discovered that misreading of therapeutic mRNAs by the cell’s decoding machinery can cause an unintended immune response in the body. They have identified the sequence within the mRNA that causes this to occur and found a way to prevent ‘off-target’ immune responses to enable the safer design of future mRNA therapeutics.

Read the full story on University of Cambridge news.

'(N)1-methylpseudouridylation of mRNA causes +1 ribosomal frameshifting' was published in Nature on 6th December 2023. Read the full publication here.

We would like to thank our Proteomics Facility for their support with this study.