Yesterday at the British Toxicology Society Congress, our Unit Director Professor Anne Willis delivered the John Barnes Prize lecture, focusing on mechanistic toxicology to improve human health. This award was established in memory of Dr John Barnes, who was the Director from the establishment of MRC Toxicology Unit in...

Eve Stalker, a PhD student in the Willis Lab, and Dr Miriam Cipullo, a Postdoctoral Fellow joint between AstraZeneca and the MacFarlane Lab at the MRC Toxicology Unit were awarded prizes at the joint BTS-BPS Meeting ‘Toxicology in a New Era of Pharmacology’. The one-day conference brought together experts across...

Our Unit Director Prof Anne Willis has been awarded the prestigious John Barnes Prize Award from the British Toxicology Society . Prof Willis leads a research group investigating the role of post-transcriptional control in response to toxic injury with a focus on RNA-binding proteins, regulatory RNA motifs and tRNAs and...

Trials of a cancer 'vaccine' have begun. The vaccine is based on the same mRNA technology as the Pfizer-BioNTech COVID-19 vaccines. As part of this latest episode of BBC Radio 4's Inside Health programme, James Gallagher visits the Unit and speaks to Prof Anne Willis and Dr James Thaventhiran about how the vaccine is...

Work published by Prof Anne Willis and Dr James Thaventhiran, alongside collaborators in Kent, Oxford and Liverpool, describing how mRNA therapeutics may cause an unintended immune response and need fine-tuning for the future was reported across multiple national and international media outlets. You can read the Unit's...

Researchers from the Willis and Thaventhiran labs have discovered that misreading of therapeutic mRNAs by the cell’s decoding machinery can cause an unintended immune response in the body. They have identified the sequence within the mRNA that causes this to occur and found a way to prevent ‘off-target’ immune responses to...

You might imagine the cells in your body as quite static. In reality, they are hives of activity and contain cocktails of different molecules. Just like us, these different molecules in our cells all have a job. Just like us, those jobs span a wide range of roles and take place in designated spaces – instead of offices or...

Cancer is something that has impacted all of us either directly or indirectly and is a leading cause of death globally. As a result, there is an urgent and ongoing need to discover and develop new treatments to tackle this disease more efficiently. Interestingly, most of the small-molecule drugs that have been approved as...

We are delighted to share the news that Prof Anne Willis and Dr Ritwick Sawarkar are a part of a consortium that has been awarded £8 million by the Nucleic Acid Therapy Accelerator (NATA) to enhance the UK's nucleic acid therapeutics delivery platforms. The consortium, led by Professor Matthew Wood at the University of...

The 1st episode of the British Toxicology Society's 'Flying the NEST' podcast features Unit Director Prof Anne Willis. In this episode, Anne discusses her career path so far, what she wishes she had known at the start of her career and insights in the Unit's research. Listen online now . The British Toxicology Society (BTS...