Trials of a cancer 'vaccine' have begun. The vaccine is based on the same mRNA technology as the Pfizer-BioNTech COVID-19 vaccines. As part of this latest episode of BBC Radio 4's Inside Health programme, James Gallagher visits the Unit and speaks to Prof Anne Willis and Dr James Thaventhiran about how the vaccine is...

New research from the Thaventhiran lab in collaboration with the groups of Florian Hollfelder , Marko Hyvonen , Nick Matheson and Charlotte Deane establishes a new, generalised technology for finding potentially therapeutic antibodies in response to infectious disease outbreaks faster than currently possible.

Researchers at the MRC Toxicology Unit have developed a new mouse model for tracking the behaviour of immune cells once an immune response is triggered. This could help scientists to understand how our immune system responds to different insults in more detail to develop new and improved immune therapies. Our body triggers...

Our gut microbiome is home to a diverse mix of microorganisms that are delicately balanced to preserve many aspects of our health including digestion, immunity and even our mental wellbeing. There are known factors that can impact our microscopic companions such as diet, lifestyle, antibiotic use and environmental...

Work published by Prof Anne Willis and Dr James Thaventhiran, alongside collaborators in Kent, Oxford and Liverpool, describing how mRNA therapeutics may cause an unintended immune response and need fine-tuning for the future was reported across multiple national and international media outlets. You can read the Unit's...

Researchers from the Willis and Thaventhiran labs have discovered that misreading of therapeutic mRNAs by the cell’s decoding machinery can cause an unintended immune response in the body. They have identified the sequence within the mRNA that causes this to occur and found a way to prevent ‘off-target’ immune responses to...

The Mirror covered the latest exciting research from the Thaventhiran lab in collaboration with researchers across the University of Cambridge. Described as a "huge step forward" by Dr Miriam Stoppard, the discovery made by Unit researchers may explain why, even among vulnerable patient groups, some have better responses...

Researchers from the MRC Toxicology Unit have identified a signature in the blood that could help predict how well an individual will respond to vaccines. The discovery, published today in the journal Nature Communications, may explain why, even among vulnerable patient groups, some individuals have better responses to...

Work published by Dr James Thaventhiran and collaborators in Cambridge and Edinburgh describing how obesity accelerates the loss of protection from COVID-19 vaccines was reported across national media outlets. Dr Thaventhiran was also interviewed about their findings on local radio. You can read the Unit's news article and...

The protection offered by COVID-19 vaccination declines more rapidly in people with severe obesity compared to those with normal weight, researchers from the MRC Toxicology Unit and collaborators within the Universities of Cambridge and Edinburgh have found. The study suggests that people with obesity are likely to need...