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Air pollution from brake dust may have same harmful effects on immune cells as diesel exhaust

20 January 2020

Metal particles from the abrasion of brake pads - up to a fifth of fine particulate matter (PM2.5) air pollution at roadsides - may cause inflammation and reduce the ability of immune cells to kill bacteria, a new study has found, similarly to particles derived from diesel exhaust. The scientists, primarily funded by the...

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PhD Studentships Available

15 January 2020

The MRC Toxicology Unit is now advertising for four PhD Studenstships commencing in October 2020. The four projects are: Toxicity-induced phase separation of transcriptional regulators: mechanisms and cellular consequences - Supervisor: Dr Ritwick Sawarkar Single Cell assessment of adaptive immune clonal expansion and...

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New exciting paper from the Willis Lab

18 December 2019

We are pleased to announce a new paper from the Willis lab, which made front cover of science signaling, shows the common chemotherapy doxorubicin can promote the migration of cancer cells through phosphorylation of a translation factor. Please see the links to the article published in Science Signaling below: Summary...

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Welcome to our new group leaders

22 October 2019

The Unit is delighted to announce the appointment of three new group leaders: Mike Chapman, Ritwick Sawarkar and Kiran Patil. Mike Chapman Mike’s programme will focus on the toxicity of CAR-T cell therapy. The lab will be combining genomic and proteomic approaches with more traditional ‘wet lab’ techniques to dissect the...

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Welcome to Dr Mathew Van de Pette

18 September 2019

The Unit is delighted to announce that Dr Mathew Van de Pette has joined on 1st September as Programme Leader Track. Mat's programme is aimed at understanding the mechanisms by which environmental stressors induce changes to epigentic pathways in utero.

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Poster Prize - Marco Travaglio

22 May 2019

Marco, a PhD student in the group of Lia Panman, has won a prize for his poster about dopaminergic axon guidance at the DDSSCC meeting held in Crete (13th -15th of May). This prize allows him to attend another course or conference organized by CamBioscience for free.

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Professor Andy Smith gives Barnes Award Lecture at the BTS Annual Congress

29 April 2019

Professor Andy Smith, Head of the Integrative Toxicology Training Partnership (ITTP) at the MRC Toxicology Unit in Leicester, was nominated to deliver the 2019 Barnes Prize Lecture on 16 April at the British Toxicology Society (BTS) Annual Congress in Cambridge. The award was established in memory of Dr John Barnes, a...

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Catching lung cancer early using only a sample of blood

14 February 2019

In this video, a summary of Miguel’s group latest study, modelling pre-cancerous lung tumours in mice to determine if evidence of these early tumours could be detected in the blood

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Dr Martin Johnson –Neuropathy Target Esterase

24 December 2018

The MRC Toxicology Unit is sad to note the decease of Dr Martin Johnson a retired long-standing member of the Unit and British Toxicology Society. Over many years Martin meticulously investigated the target of some organophosphorus insecticides that cause degeneration of axons in the spinal cord and peripheral nerves. This...

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'PAXX and its paralogs synergistically direct DNA polymerase λ activity in DNA repair'

25 September 2018

Published in @NatureComms today by scientists at @MRC_TU - 'PAXX and its paralogs synergistically direct DNA polymerase λ activity in DNA repair'

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