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Key Publications:

1. Design of nucleotide-mimetic and non-nucleotide inhibitors of the translation initiation factor eIF4E: Synthesis, structural and functional characterisation.
Soukarieh F, Nowicki MW, Bastide A, Pöyry T, Jones C, Dudek K, Patwardhan G, Meullenet F, Oldham NJ, Walkinshaw MD, Willis AE, Fischer PM.
Eur J Med Chem. 2016 Nov 29;124:200-217. doi: 10.1016/j.ejmech.2016.08.047.

2. Cap-Independent Translation in Hematological Malignancies.
Horvilleur E, Wilson LA, Bastide A, Piñeiro D, Pöyry TA, Willis AE.
Front Oncol. 2015 Dec 21;5:293. doi: 10.3389/fonc.2015.00293

3. A common polymorphism in the 5′ UTR of ERCC5 creates an upstream ORF that confers resistance to platinum-based chemotherapy.
Somers J, Wilson LA, Kilday JP, Horvilleur E, Cannell IG, Pöyry TA, Cobbold LC, Kondrashov A, Knight JR, Puget S, Grill J, Grundy RG, Bushell M, Willis AE.
Genes Dev. 2015 Sep 15;29(18):1891-6. doi: 10.1101/gad.261867.115

4. A perspective on mammalian upstream open reading frame function.
Somers J, Pöyry T, Willis AE.
Int J Biochem Cell Biol. 2013 Aug;45(8):1690-700. doi: 10.1016/j.biocel.2013.04.020.

5. Mechanisms governing the selection of translation initiation sites on foot-and-mouth disease virus RNA.
Pöyry TA, Jackson RJ.
J Virol. 2011 Oct;85(19):10178-88. doi: 10.1128/JVI.05085-11

6. Activation of a microRNA response in trans reveals a new role for poly(A) in translational repression.
Ricci EP, Limousin T, Soto-Rifo R, Allison R, Pöyry T, Decimo D, Jackson RJ, Ohlmann T.
Nucleic Acids Res. 2011 Jul;39(12):5215-31. doi: 10.1093/nar/gkr086.

7. Further characterisation of the translational termination-reinitiation signal of the influenza B virus segment 7 RNA.
Powell ML, Leigh KE, Pöyry TA, Jackson RJ, Brown TD, Brierley I.
PLoS One. 2011 Feb 8;6(2):e16822. doi: 10.1371/journal.pone.0016822.

8. Mechanism of initiation site selection promoted by the human rhinovirus 2 internal ribosome entry site.
Kaminski A, Pöyry TA, Skene PJ, Jackson RJ.
J Virol. 2010 Jul;84(13):6578-89. doi: 10.1128/JVI.00123-10

9. Polypyrimidine tract binding protein stabilizes the encephalomyocarditis virus IRES structure via binding multiple sites in a unique orientation.
Kafasla P, Morgner N, Pöyry TA, Curry S, Robinson CV, Jackson RJ.
Mol Cell. 2009 Jun 12;34(5):556-68. doi: 10.1016/j.molcel.2009.04.015.

10. The mechanism of an exceptional case of reinitiation after translation of a long ORF reveals why such events do not generally occur in mammalian mRNA translation.
Pöyry TA, Kaminski A, Connell EJ, Fraser CS, Jackson RJ.
Genes Dev. 2007 Dec 1;21(23):3149-62.

11. Intracellular localization and effects of individually expressed human parechovirus 1 non-structural proteins.
Krogerus C, Samuilova O, Pöyry T, Jokitalo E, Hyypiä T.
J Gen Virol. 2007 Mar;88(Pt 3):831-41.

12. Specific interaction between human parechovirus nonstructural 2A protein and viral RNA.
Samuilova O, Krogerus C, Pöyry T, Hyypiä T.
J Biol Chem. 2004 Sep 3;279(36):37822-31

Publications

Other publications: 

 

13. What determines whether mammalian ribosomes resume scanning after translation of a short upstream open reading frame?
Pöyry TA, Kaminski A, Jackson RJ.
Genes Dev. 2004 Jan 1;18(1):62-75.

14. Variation in enterovirus receptor genes.
Karttunen A, Pöyry T, Vaarala O, Ilonen J, Hovi T, Roivainen M, Hyypiä T.
J Med Virol. 2003 May;70(1):99-108.

15. Poliovirus internal ribosome entry segment structure alterations that specifically affect function in neuronal cells: molecular genetic analysis.
Malnou CE, Pöyry TA, Jackson RJ, Kean KM.
J Virol. 2002 Nov;76(21):10617-26.

Research Fellow (MRC)

Contact Details

MRC Toxicology Unit
Gleeson Building
Tennis Court Road
Cambridge

CB2 1QR

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+44 (0)1223 3 34866

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