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Biography:

I studied and got my MSc in Chemistry and Pharmaceutical Technologies at the University of Padua, working on a thesis in Prof. Margherita Morpurgo Lab, about the delivery of drugs using nanoparticles. After that, I did my Ph.D. in Prof. Michael Y Sherman lab in Israel. During my studies, I tried to understand how the HSP70-Bag3 complex would transduce the proteotoxic stress signal to different pathways, taking as an example the Hippo-YAP pathway. In March 2023, I joined the Sawarkar group, following my interest in understanding how cells respond to stress, in specific proteotoxic stress, at in vitro and in vivo levels.

Research interests:

In my period with the Sawarkar group, I will be trying to understand the role of proteostasis in cell size control, and I will try to understand how stress can impact the homeostasis of the cell size, at in vitro and in vivo levels.

 

Publications

Key publications: 

Baldan S, Meriin AB, Yaglom J, Alexandrov I, Varelas X, Xiao ZJ, Sherman MY. The Hsp70-Bag3 complex modulates the phosphorylation and nuclear translocation of Hippo pathway protein Yap. J Cell Sci. 2021 Dec 1;134(23):jcs259107. doi: 10.1242/jcs.259107

Violatto MB, Casarin E, Talamini L, Russo L, Baldan S, Tondello C, Messmer M, Hintermann E, Rossi A, Passoni A, Bagnati R, Biffi S, Toffanin C, Gimondi S, Fumagalli S, De Simoni MG, Barisani D, Salmona M, Christen U, Invernizzi P, Bigini P, Morpurgo M. Dexamethasone Conjugation to Biodegradable Avidin-Nucleic-Acid-Nano-Assemblies Promotes Selective Liver Targeting and Improves Therapeutic Efficacy in an Autoimmune Hepatitis Murine Model. ACS Nano. 2019 Apr 23;13(4):4410-4423. doi: 10.1021/acsnano.8b09655.

Patel S, Kumar S, Baldan S, Hesin A, Yaglom J, Sherman MY. Cytoplasmic proteotoxicity regulates HRI-dependent phosphorylation of eIF2α via the Hsp70-Bag3 module. iScience. 2022 Apr 22;25(5):104282. doi: 10.1016/j.isci.2022.104282.

Research Associate

Contact Details

MRC Toxicology Unit
Gleeson Building
Tennis Court Road
Cambridge

CB2 1QR

Telephone and Email

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