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Biography:

Sarah trained in Medicine at the University of Edinburgh, with an intercalated BMedSci in Experimental Pathology and postgraduate MSc in Translational Medicine. She completed her Histopathology training in Cambridge as an NIHR Academic Clinical Fellow and subsequently NIHR Clinical Lecturer. She undertook a mixed experimental-computational PhD at the CRUK Cambridge Institute, followed by a bioinformatics fellowship at the IRB Barcelona. Sarah started her research group at the MRC Toxicology Unit in 2021 and is also a practicing clinician at Addenbrooke’s Hospital, Cambridge.

Key Publications:

Full publication list

 

1. SJ Aitken, CJ Anderson, F Connor, O Pich, V Sundaram, C Feig, TF Rayner, M Lukk, S Aitken, J Luft, E Kentepozidou, C Arnedo-Pac, SV Beentjes, SE Davies, RM Drews, A Ewing, VB Kaiser, A Khamseh, E López-Arribillaga, AM Redmond, J Santoyo-Lopez, I Sentís, L Talmane, AD Yates, Liver Cancer Evolution Consortium, CA Semple, N López-Bigas, P Flicek, DT Odom, MS Taylor. Pervasive lesion segregation shapes cancer genome evolution. Nature. 2020;583:265-270.

https://www.nature.com/articles/s41586-020-2435-1

 

2. E Kentepozidou, SJ Aitken, C Feig, K Stefflova, X Ibarra-Soria, DT Odom, M Roller, P Flicek. Clustered CTCF binding is an evolutionary mechanism to maintain topologically associating domains. Genome Biology. 2020;21:5.

https://genomebiology.biomedcentral.com/articles/10.1186/s13059-019-1894-x

 

3. SF Brunner, ND Roberts, LA Wylie, L Moore, SJ Aitken, SE Davies, M Sanders, P Ellis, C Alder, Y Hooks, F Abascal, MR Stratton, I Martincorena, M Hoare, PJ Campbell. Somatic mutations and clonal dynamics in healthy and cirrhotic human liver. Nature. 2019;574:538-542.

https://www.nature.com/articles/s41586-019-1670-9

 

4. F Connor, TF Rayner, SJ Aitken, C Feig, M Lukk, J Santoyo-Lopez, DT Odom. Mutational landscape of a chemically induced mouse model of liver cancer. Journal of Hepatology. 2018;69(4):840-850.

https://www.journal-of-hepatology.eu/article/S0168-8278(18)32162-7/fulltext

 

5. SJ Aitken*, X Ibarra-Sor­ia*, E Kentepozidou, P Flicek, C Feig, JC Marioni, DT Odom. CTCF maintains regulatory homeostasis of cancer pathways. Genome Biology. 2018;19:106. *SJA and XIS contributed equally.

https://genomebiology.biomedcentral.com/articles/10.1186/s13059-018-1484-3

Group Leader

Contact Details

MRC Toxicology Unit
Gleeson Building
Tennis Court Road
Cambridge

CB2 1QR

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