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Biography:

2023-Present Head of Proteomics Facility at MRC Toxicology Unit

2019-2023 Postdoctoral Fellow at the Buck Institute for Research on Aging, Novato, California, USA.
Research topic: Leveraging proteomics technologies to unravel the impact of senescence-associated secretory phenotypes (SASP), particularly small extracellular vesicles (sEVs), in the processes of aging, age-related ailments, and overall health.

2011-2019 M.Sc.-Ph.D. dual degree at Indian Institute of Technology Bombay (IITB), Mumbai, Maharashtra, India.
Research topic: Utilizing proteomics and metabolomics tools to identify and validate early diagnostic, prognostic, and recovery biomarkers for Plasmodium vivax malaria.

2008-2011 B.Sc. Zoology (Honours) at Banaras Hindu University (BHU), Varanasi, Uttar Pradesh, India.

 

Research interests:

As the Head of Proteomics, I am dedicated to steering our mass spectrometry-based proteomics research in alignment with our institutional objectives. My role encompasses overseeing all facets of the proteomics facility, from personnel management to instrument maintenance, ensuring seamless operations and adherence to rigorous quality standards and regulatory requirements. I actively foster collaborations with fellow researchers, advocating for our facility's expertise at scientific gatherings, and nurturing strategic alliances with leading mass spectrometry vendors. Also, I orchestrate tailored training sessions for both senior leaders and junior researchers, empowering them with the necessary skills to excel in their endeavors. Ultimately, my aim is to facilitate impactful research outcomes that contribute to our broader scientific community.

 

 

Publications

Key publications: 

1. Garcia-Martin R, Wang G, Brandão BB, Zanotto TM, Shah S, Patel SK, Schilling B, Kahn CR (2022) MicroRNA sequence codes for small extracellular vesicle release and cellular retention. Nature, 601:446–451. doi:10.1038/s41586-021-04234-3
2. Fuentes‐Flores A, Geronimo‐Olvera C, Girardi K, Necuñir‐Ibarra D, Patel SK, Bons J, Wright MC, Geschwind D, Hoke A, Gomez‐Sanchez JA, Schilling B, Rebolledo DL, Campisi J, Court FA (2023) Senescent Schwann cells induced by aging and chronic denervation impair axonal regeneration following peripheral nerve injury. EMBO Molecular Medicine, 15: e17907. doi:10.15252/emmm.202317907
3. Rai V*, Patel SK*, Muthuraj M, Gandhi MN, Das D, Srivastava S (2021) Systematic metabolome profiling and multi-omics analysis of the nitrogen-limited non-model oleaginous algae for biorefining. Biofuel Res Journal, 8(1): 1330-1341. doi: 10.18331/BRJ2021.8.1.4
4. Patel SK, Rajora N, Kumar S, Sahu A, Kochar S, Krishna CM, Srivastava S (2018) Rapid discrimination of Malaria and Dengue Infected Patient Sera using Raman Spectroscopy. Analytical Chemistry, 91(11):7054-7062. doi: 10.1021/acs.analchem.8b05907
5 Ray S*, Patel SK*, Venkatesh A, Bhave A, Kumar V, Singh V, Chatterjee G, Shah VG, Sharma S, Renu D, Nafis N, Gandhe P, Gogtay N, Thatte U, Sehgal K, Verma S, Karak A, Khanra D, Talukdar A, Kochar SK, Vijeth SB, Kochar DK, Rojh D, Varma SG, Gandhi MN, Srikanth R, Patankar S, Srivastva S. (2016) Clinicopathological analysis and multipronged quantitative proteomics reveal oxidative stress and cytoskeletal proteins as possible markers for severe vivax malaria. Scientific Reports, 6: 24557. doi:10.1038/srep24557

Proteomics Facility Manager

Contact Details

MRC Toxicology Unit
Gleeson Building
Tennis Court Road
Cambridge

CB2 1QR

Telephone and Email

Affiliations

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