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Biography

Ritwick studied Microbiology and Biochemistry in Mumbai (India) and obtained his PhD in 2010 from Indian Institute of Science, Bangalore. Ritwick then moved to the Department of Biosystems Science and Engineering of ETH-Zürich in Basel (Switzerland) as a postdoctoral fellow with Renato Paro. In 2014, Ritwick started his own independent group at the Max Planck Institute of Immunobiology and Epigenetics in Freiburg (Germany), before moving to the MRC Toxicology Unit in 2019. Ritwick received the ERC Consolidator Grant in 2018 and Alfred Tissières Young Investigator Award in 2019.

Publications

Key publications: 

Rawat P, Boehning M, Hummel B, Aprile-Garcia F, Pandit AS, Eisenhardt N, Khavaran A, Niskanen E, Vos SM, Palvimo JJ, Pichler A, Cramer P, Sawarkar R. (2021) Stress-induced nuclear condensation of NELF drives transcriptional downregulation. Mol Cell. doi: 10.1016/j.molcel.2021.01.016. 

Antonova A, Hummel B, Khavaran A, Redhaber D, Aprile Garcia F, Rawat P, Gundel K, Schneck M, Hansen E, Mitschke J, Mittler G, Miething C and Sawarkar R (2019) Heat-shock protein 90 controls the expression of cell-cycle genes by stabilizing metazoan-specific Host-Cell Factor HCFC1. Cell Reports. 29(6):1645-1659.e9.

Aprile-Garcia F, Tomar P, Hummel B, Khavaran A and Sawarkar R (2019) Nascent-protein ubiquitination is required for heat-shock induced gene downregulation. Nature Structural and Molecular Biology. 26(2):137-146.

Irmak D, Fatima A, Gutiérrez-Garcia R, Rinschen MM, Wagle P, Altmüller J, Arrigoni L, Hummel B, Klein C, Frese CK, Sawarkar R, Rada-Iglesias A, Vilchez D. (2018) Mechanism suppressing H3K9 trimethylation in pluripotent stem cells and its demise by polyQ-expanded huntingtin mutations. Hum Mol Genet. 27(23):4117-4134.

Vincenz-Donnelly L, Holthusen H, Körner R, Hansen EC, Presto J, Johansson J, Sawarkar R, Hartl FU, Hipp MS. (2017) High capacity of the endoplasmic reticulum to prevent secretion and aggregation of amyloidogenic proteins. EMBO. e201695841.

Hummel, B., Hansen, E.C., Yoveva, A., Aprile-Garcia, F., Hussong, R., and Sawarkar, R. (2017). The evolutionary capacitor HSP90 buffers the regulatory effects of mammalian endogenous retroviruses. Nature structural & molecular biology 24, 234-242.

Sawarkar R, Sievers C and Paro R (2012) Hsp90 globally targets paused RNA polymerase to regulate gene expression in response to stimuli. Cell. 149(4):807-18.

MRC Investigator

Contact Details

MRC Toxicology Unit
Gleeson Building
Tennis Court Road
Cambridge

CB2 1QR

Telephone and Email

+44 (0)1223 3 34706

Affiliations

Classifications: 
Specialities: