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Mathew obtained a PhD in Genetics from Cardiff University working on dosage modifications of an imprinted gene, Cdkn1c.  He then moved to London to work with Dame Professor Amanda Fisher in the MRC London Institute of Medical Sciences (LMS), where he also held a Junior Research Fellowship. During this time, he worked to develop novel models for studying epigenetics longitudinally, including establishing a number of transgenic mouse lines that enable non-invasive reporter imaging. This is his first independent research position.


Research Interests:

My lab is interested in Developmental and Reproductive Toxicology (DART). We use both in vivo and in vitro approaches to explore the impact of human relevant doses of Epidrugs. Using reporter models of epigenetic state, we aim to distinguish short term epigenetic changes following drug exposure, and lasting changes that will be present throughout life, and potentially into the next generation(s). We collaborate with industrial and academic partners, applying an array of molecular biology techniques to answer key mechanistic questions.



Key publications: 

Van de Pette M, Dimond A, Galvão AM, Millership SJ, To W, Prodani C, McNamara G, Bruno L, Sardini A, Webster Z, McGinty J, French PMW, Uren AG, Castillo-Fernandez J, Watkinson W, Ferguson-Smith AC, Merkenschlager M, John RM, Kelsey G and Fisher AG. Epigenetic changes induced by in utero dietary challenge result in phenotypic variability in successive generations of miceNature Communications; 13, 2464. (2022).

Van de Pette M, Abbas A, Feytout A, McNamara G, Bruno L, To WK, Dimond A, Sardini A, Webster Z, McGinty J, Paul EJ, Ungless MA, French PMW, Withers DJ, Uren A, Ferguson-Smith AC, Merkenschlager M, John RM and Fisher AG. Visualizing changes in Cdkn1c expression links early-life adversity to imprint mis-regulation in adultsCell Reports; 18 (5), 1090-1099. (2017).

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MRC Investigator

Contact Details

MRC Toxicology Unit
Gleeson Building
Tennis Court Road


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