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Key Publications:

1. RNA binding protein/RNA element interactions and the control of translation.
Pichon X, Wilson LA, Stoneley M, Bastide A, King HA, Somers J, Willis AE.
Curr Protein Pept Sci. 2012 Jun;13(4):294-304. Review.

2. Translational reprogramming following UVB irradiation is mediated by DNA-PKcs and allows selective recruitment to the polysomes of mRNAs encoding DNA repair enzymes.
Powley IR, Kondrashov A, Young LA, Dobbyn HC, Hill K, Cannell IG, Stoneley M, Kong YW, Cotes JA, Smith GC, Wek R, Hayes C, Gant TW, Spriggs KA, Bushell M, Willis AE.
Genes Dev. 2009 May 15;23(10):1207-20. doi: 10.1101/gad.516509.
3. Canonical initiation factor requirements of the Myc family of internal ribosome entry segments.
Spriggs KA, Cobbold LC, Jopling CL, Cooper RE, Wilson LA, Stoneley M, Coldwell MJ, Poncet D, Shen YC, Morley SJ, Bushell M, Willis AE.
Mol Cell Biol. 2009 Mar;29(6):1565-74. doi: 10.1128/MCB.01283-08

4. The mechanism of micro-RNA-mediated translation repression is determined by the promoter of the target gene.
Kong YW, Cannell IG, de Moor CH, Hill K, Garside PG, Hamilton TL, Meijer HA, Dobbyn HC, Stoneley M, Spriggs KA, Willis AE, Bushell M.
Proc Natl Acad Sci U S A. 2008 Jul 1;105(26):8866-71. doi: 10.1073/pnas.0800650105

5. SF2/ASF TORCs up translation.
Bushell M, Stoneley M, Spriggs KA, Willis AE.
Mol Cell. 2008 May 9;30(3):262-3. doi: 10.1016/j.molcel.2008.04.007
6. Re-programming of translation following cell stress allows IRES-mediated translation to predominate.
Spriggs KA, Stoneley M, Bushell M, Willis AE.
Biol Cell. 2008 Jan;100(1):27-38. Review
7. Polypyrimidine tract binding protein regulates IRES-mediated gene expression during apoptosis.
Bushell M, Stoneley M, Kong YW, Hamilton TL, Spriggs KA, Dobbyn HC, Qin X, Sarnow P, Willis AE.
Mol Cell. 2006 Aug 4;23(3):401-12.
8. Identification of a motif that mediates polypyrimidine tract-binding protein-dependent internal ribosome entry.
Mitchell SA, Spriggs KA, Bushell M, Evans JR, Stoneley M, Le Quesne JP, Spriggs RV, Willis AE.
Genes Dev. 2005 Jul 1;19(13):1556-71.
10. Cellular internal ribosome entry segments: structures, trans-acting factors and regulation of gene expression.
Stoneley M, Willis AE.
Oncogene. 2004 Apr 19;23(18):3200-7. Review.
11. L-Myc protein synthesis is initiated by internal ribosome entry.
Jopling CL, Spriggs KA, Mitchell SA, Stoneley M, Willis AE.
RNA. 2004 Feb;10(2):287-98.
12. Aberrant regulation of translation initiation in tumorigenesis.
Stoneley M, Willis AE.
Curr Mol Med. 2003 Nov;3(7):597-603. Review.
Senior Investigator Scientist

Contact Details

MRC Toxicology Unit
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