Dr Nobuhiro Morone

  • Senior Investigator Scientist and Facility Head
Dr Nobuhiro Morone

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About

Biography:

2025-Present Executive Editor, Microscopy (Oxford Academic), Oxford University Press, Oxford UK.

2015-Present Senior Investigator Scientist & Facility Head of Electron Microscopy & Ultrastructural Pathology at MRC Toxicology Unit and Visiting Professor at iCeMS/KUIAS Kyoto University, Kyoto, Japan.

2010-2015 Senior Lecturer at iCeMS Kyoto University, Kyoto, Japan.

2005-2010 Section Chief at National Institute of Neuroscience, National Centre of Neurology and Psychiatry, Tokyo, Japan.

2004-2005 PI at Mitsubishi Kagaku Institute of Life Sciences, Tokyo, Japan.

1999-2003 Postdoctoral at ERATO-JST/Nagoya University, Nagoya, Japan.

1999 PhD (Kyoto University, Japan) Synthetic & Biological Chemistry.

 

Research Interests:

Nobu’s research in the Unit is based on “EM-based nano-toxicology” for visual understanding the role of endocytosis at the plasma membrane and membrane recycling among the intracellular organelle compartments affected by toxins or drugs for mesothelioma in immune-oncology and neurogenerative diseases as well. Nobu’s EM covers a whole range of cellular tissues from the mouse brain to the signalling receptor-complexes by using both classic and advanced microscopy from deep-etch EM and cryo-EM (single particle analysis and tomography). Nobu’s future goal is to determine the atomic structure of crucial membrane machinery (caveolae with MSK) and chromatin complex in situ by the hybrid EM correlation, as well as to establish a lesion detection system under EM resolution by a template matching method toward tumour and neurogenerative diseases.

UK-Japan Structural Life Science Forum (Chair)

As the chair for UK-Japan Structural Life Science Forum, Nobu has co-organised a series of international meetings for state-of-the-art electron microscopy.

  • 2017 Leicester - Frontiers in Cryo Electron Microscopy. Special Notes: Keynote Richard Henderson (MRC-LMB, Cambridge) received the Nobel Prize in Chemistry 2017 at the Forum!
  • 2019 Bristol - Frontiers in Cellular, Viral and Molecular Microscopy with Cryo-specimen Preparation Techniques.
  • 2026 Kyoto - Expanding the borders of cryo-EM Single Particle Analysis and and Tomography. Special Notes: Osamu Hayaishi Memorial Lecture by Richard Henderson (MRC-LMB, Cambridge).

Publications

Selected publications

Human gut bacteria bioaccumulate per- and polyfluoroalkyl substances Lindell AE, Grießhammer A, Michaelis L, Papagiannidis D, Ochner H, Kamrad S, Guan R, Blasche S, Ventimiglia LN, Ramachandran B, Ozgur H, Zelezniak A, Beristain-Covarrubias N, Yam-Puc JC, Roux I, Barron LP, Richardson AK, Martin MG, Benes V, Morone N,, Thaventhiran JED, Bharat TAM, Savitski MM, Maier L, Patil KR TAp73 regulates mitochondrial dynamics and multiciliated cell homeostasis through an OPA1 axis Buckley NA, Craxton A, Sun XM, Panatta E, Pinon LG, Beier S, Kalmar L, Llodrá J, Morone N, Amelio I, Melino G, Martins LM, MacFarlane M Micro-second time-resolved X-ray single-molecule internal motions of SARS-CoV-2 spike variants. Sasaki D, Arai T, Yang Y, Kuramochi M, Furuyama W, Nanbo A, Sekiguchi H, Morone N, Mio K, Sasaki YC Cholesterol- and actin-centered view of the plasma membrane: updating the Singer-Nicolson fluid mosaic model to commemorate its 50th anniversary. Kusumi A, Tsunoyama TA, Tang B, Hirosawa KM, Morone N, Fujiwara TK, Suzuki KGN Capturing human trophoblast development with naive pluripotent stem cells in vitro Io S, Kabata M, Iemura Y, Semi K, Morone N, Minagawa A, Wang B, Okamoto I, Nakamura T, Kojima Y, Iwatani C, Tsuchiya H, Kaswandy B, Kondoh E, Kaneko S, Woltjen K, Saitou M, Yamamoto T, Mandai M, Takashima Y Cryo-EM structural analysis of FADD:Caspase-8 complexes defines the catalytic dimer architecture for co-ordinated control of cell fate Fox JL, Hughes MA, Meng X, Sarnowska NA, Powley IR, Jukes-Jones R, Dinsdale D, Ragan TJ, Fairall L, Schwabe JWR, Morone N, Cain K, MacFarlane M Improved unroofing protocols for cryo-electron microscopy, atomic force microscopy and freeze-etching electron microscopy and the associated mechanisms Morone N, Usukura E, Narita A, Usukura J. Mechanism of crosstalk between the LSD1 demethylase and HDAC1 deacetylase in the CoREST complex Song Y, Dagil L, Fairall L, Robertson N, Wu M, Ragan TJ, Savva CG, Saleh A, Morone N, Kunze MBA, Jamieson AG, Cole PA, Hansen DF, Schwabe JWR Hybrid Cellular Metabolism Coordinated by Zic3 and Esrrb Synergistically Enhances Induction of Naive Pluripotency Sone M, Morone N, Nakamura T, Tanaka A, Okita K, Woltjen K, Nakagawa M, Heuser JE, Yamada Y, Yamanaka S, Yamamoto T Cells respond to mechanical stress by rapid disassembly of caveolae Sinha B, Köster D, Ruez R, Gonnord P, Bastiani M, Abankwa D, Stan RV, Butler- Browne G, Vedie B, Johannes L, Morone N, Parton RG, Raposo G, Sens P, Lamaze C, Nassoy P