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I completed my Master Degree in Physics and worked initially in industry as an industrial physicist, before joining the Picard Lab in the Department of Molecular and Cellular Biology at the University of Geneva focusing on molecular chaperone heat-shock protein 90 (Hsp90), Malaria, and steroid receptors.

Research interests:

Hsp90; protein-protein interactions; RNA Biology



Key publications: 

Hsf1 and the molecular chaperone Hsp90 support a "rewiring stress response" leading to an adaptive cell size increase in chronic stress, Samarpan Maiti; Kaushik Bhattacharya; Diana Wider; Dina Hany; Olesya Panasenko; Lilia Bernasconi; Nicolas Hulo; Didier Picard,
Preprint: January 2023, DOI 10.1101/2023.01.25.525547

Translational reprogramming in response to accumulating stressors ensures critical threshold levels of Hsp90 for mammalian life. Kaushik Bhattacharya; Samarpan Maiti; Szabolcs Zahoran; Lorenz Weidenauer; Dina Hany; Diana Wider; Lilia Bernasconi; Manfredo Quadroni; Martine Collart; Didier Picard,
Nature Communications: October 2022, DOI 10.1038/s41467-022-33916-3

The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation. Kaushik Bhattacharya; Lorenz Weidenauer; Tania Morán Luengo; Ellis C. Pieters; Pablo C. Echeverría; Lilia Bernasconi; Diana Wider; Yashar Sadian; Margreet B. Koopman; Matthieu Villemin et al.,
Nature Communications: November 2020, URL 10.1038/s41467-020-19783-w

Secreted dual reporter assay with Gaussia luciferase and the red fluorescent protein mCherry. Diana Wider; Didier Picard,
PloS one: December 2012, DOI 10.1371/journal.pone.0189403

LSD1 engages a corepressor complex for the activation of the estrogen receptor α by estrogen and cAMP. Bennesch MA; Segala G; Wider D; Picard `D,
Nucleic acids research: June 2016, DOI 10.1093/nar/gkw522

The complementation of yeast with human or Plasmodium falciparum Hsp90 confers differential inhibitor sensitivities. Wider D; Péli-Gulli MP; Briand PA; Tatu U; Picard D,
Molecular and biochemical parasitology: April 2009, DOI 10.1016/j.molbiopara.2008.12.011

Research Associate

Contact Details

MRC Toxicology Unit
Gleeson Building
Tennis Court Road