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MRC Toxicology Unit

 

Roobol A, Roobol J, Smith ME, Carden MJ, Hershey JWB, Willis AE, Smales CM. Engineered transient and stable overexpression of translation factors eIF3i and eIF3c in CHOK1 and HEK293 cells gives enhanced cell growth associated with increased c-Myc expression and increased recombinant protein synthesis. Metab Eng. 2020 May;59:98-105. doi: 10.1016/j.ymben.2020.02.001. Epub 2020 Feb 13. PMID:32061967

 

Pizzinga M, Harvey RF, Garland GD, Mordue R, Dezi V, Ramakrishna M, Sfakianos A, Monti M, Mulroney TE, Poyry T, Willis AE. The cell stress response: extreme times call for post-transcriptional measures. Wiley Interdiscip Rev RNA. 2020 May;11(3):e1578. doi: 10.1002/wrna.1578. Epub 2019 Nov 21. Review. PMID: 31755249

 

Thaventhiran J.E.D. et al. Whole-genome sequencing of a sporadic primary immunodeficiency cohort. Nature, 2020, In press, publication date 4 May 2020

 

Zhang YZ, Brambilla C, Molyneaux PL, Rice A, Robertus JL, Jordan S, Lim E, Lang-Lazdunski L, Begum S, Dusmet M, Anikin V, Beddow E, Finch J, Asadi N, Popat S, Le Quesne J, Husain AN, Cookson WO, Moffatt MF, Nicholson AG. Presence of pleomorphic features but not growth patterns improves prognostic stratification of epithelioid malignant pleural mesothelioma by 2-tier nuclear grade. Histopathology. 2020 Apr 25. doi: 10.1111/his.14127. Online ahead of print. PMID: 32333813

 

Staples E,…Thaventhiran, J.E.D. ADA2 deficiency complicated by EBV-driven lymphoproliferative disease. Clinical Immunology. In press, sent to production 22 April 2020

 

Lorenzini T, Fliegauf M, Klammer N, Frede N, Proietti M, Bulashevska A, Camacho-Ordonez N, Varjosalo M, Kinnunen M, de Vries E, van der Meer JWM, Ameratunga R, Roifman CM, Schejter YD, Kobbe R, Hautala T, Atschekzei F, Schmidt RE, Schröder C, Stepensky P, Shadur B, Pedroza LA, van der Flier M, Martínez-Gallo M, Gonzalez-Granado LI, Allende LM, Shcherbina A, Kuzmenko N, Zakharova V, Neves JF, Svec P, Fischer U, Ip W, Bartsch O, Barış S, Klein C, Geha R, Chou J, Alosaimi M, Weintraub L, Boztug K, Hirschmugl T, Dos Santos Vilela MM, Holzinger D, Seidl M, Lougaris V, Plebani A, Alsina L, Piquer-Gibert M, Deyà-Martínez A, Slade CA, Aghamohammadi A, Abolhassani H, Hammarström L, Kuismin O, Helminen M, Allen HL, Thaventhiran JE, Freeman AF, Cook M, Bakhtiar S, Christiansen M, Cunningham-Rundles C, Patel NC, Rae W, Niehues T, Brauer N, Syrjänen J, Seppänen MRJ, Burns SO, Tuijnenburg P, Kuijpers TW; NIHR-BioResource – Rare Diseases Consortium, Warnatz K, Grimbacher B. Characterization of the clinical and immunological phenotype and management of 157 individuals with 56 distinct heterozygous NFKB1 mutations. J Allergy Clin Immunol. 2020 Apr 9. pii: S0091-6749(20)30422-X. 10.1016/j.jaci.2019.11.051. [Epub ahead of print] PMID:32278790

 

Gonzalez-Ericsson PI et al. International Immuno-Oncology Biomarker Working Group. The path to a better biomarker: application of a risk management framework for the implementation of PD-L1 and TILs as immuno-oncology biomarkers in breast cancer clinical trials and daily practice. J Pathol. 2020 Apr;250(5):667-684. doi: 10.1002/path.5406. Epub 2020 Apr 9.PMID: 32129476 Review.

 

Amelio I ,Panatta E, Niklison-Chirou MV, Steinert J, Agostini M, Morone N, Knight R, Melino G. The C-terminus of p73 is essential for hippocampal development. Proc Natl Acad Sci U S A. 2020; in press.

 

Knight JRP, Garland G, Pöyry T, Mead E, Vlahov N, Sfakianos A, Grosso S, De-Lima-Hedayioglu F, Mallucci GR, von der Haar T, Smales CM, Sansom OJ, Willis AE. Control of translation elongation in health and disease. Dis Model Mech. 2020 Mar 26;13(3). pii: dmm043208. doi: 10.1242/dmm.043208. Review.  PMID: 32298235

 

Amelio I, Melino G. Context is everything: extrinsic signalling and gain-of-function p53 mutants.  Cell Death Discov. 2020;6:16. Published 2020 Mar 23. doi:10.1038/s41420-020-0251-x

 

Yufang Shi, Ying Wang, Changshun Shao, Jianan Huang, Jianhe Gan, Xiaoping Huang, Enrico Bucci, Mauro Piacentini, Giuseppe Ippolito, Gerry Melino. COVID-19 infection: the perspectives on immune responses Accepted: 10 March 2020.

 

López S, Lim EL, Horswell S, Haase K, Huebner A, Dietzen M, Mourikis TP, Watkins TBK, Rowan A, Dewhurst SM, Birkbak NJ, Wilson GA, Van Loo P, Jamal-Hanjani M; TRACERx Consortium, Swanton C, McGranahan N. Interplay between whole-genome doubling and the accumulation of deleterious alterations in cancer evolution. Nat Genet. 2020 Mar;52(3):283-293. doi: 10.1038/s41588-020-0584-7. Epub 2020 Mar 5.PMID: 32139907

 

Powley IR, Patel M, Miles G, Pringle H, Howells L, Thomas A, Kettleborough C, Bryans J, Hammonds T, MacFarlane M, Pritchard C. Patient-derived explants (PDEs) as a powerful preclinical platform for anti-cancer drug and biomarker discovery. Br J Cancer. 2020 Mar;122(6):735-744. doi: 10.1038/s41416-019-0672-6. Epub 2020 Jan 2. Review.

 

Panatta E, Lena AM, Mancini M, Smirnov A, Marini A, Delli Ponti R, Botta-Orfila T, Tartaglia GG, Mauriello A, Zhang X, Calin GA, Melino G, Candi E. Long non-coding RNA uc.291 controls epithelial differentiation by interfering with the ACTL6A/BAF complex.  EMBO Rep. 2020 Mar 4;21(3):e46734. doi: 10.15252/embr.201846734. Epub 2020 Feb 4.

 

Scialò, F; Sriram, A; Stefanatos, R; Spriggs, RV; Loh, SHY; Martins, LM; Sanz, A. Mitochondrial complex I derived ROS regulate stress adaptation in Drosophila melanogaster.   Redox Biology (2020)

 

Garrido-Maraver, J; Loh, SHY; Martins, LM; Forcing contacts between mitochondria and the endoplasmic reticulum extends lifespan in a Drosophila model of Alzheimer's disease. Biology Open (2020)

 

Alexandrova J, Piñeiro D, Jukes-Jones R, Mordue R, Stoneley M, Willis AE. Full-length NF-κB repressing factor contains an XRN2 binding domain. Biochem J. 2020 Feb 28;477(4):773-786. doi: 10.1042/BCJ20190733. PMID:32011671

 

Nicolai S, Pieraccioli M, Smirnov A, et al. ZNF281/Zfp281 is a target of miR-1 and counteracts muscle differentiation. Mol Oncol. 2020 Feb;14(2):294-308. doi: 10.1002/1878-0261.12605. PMID: 31782884

 

Smith T, Villanueva E, Queiroz RML, Dawson CS, Elzek M, Urdaneta EC, Willis AE, Beckmann BM, Krijgsveld J, Lilley KS. Organic phase separation opens up new opportunities to interrogate the RNA-binding proteome. Curr Opin Chem Biol. 2020 Feb;54:70-75. doi: 10.1016/j.cbpa.2020.01.009. Epub 2020 Mar 1. Review. PMID: 32131038

 

Shechter KR et al. Oncogenic memory underlying minimal residual disease in breast cancer.  (2020) doi:  10.1101/2020.01.23.916510

 

du Pré MF, Blazevski J, Dewan AE, Stamnaes J, Kanduri C, Sandve GK, Johannesen MK,Lindstad CB, Hnida K, Fugger L, Melino G, Qiao SW, Sollid LM. B cell tolerance and antibody production to the celiac disease autoantigen transglutaminase 2. J Exp Med. 2020 Feb 3;217(2). pii: e20190860. doi: 10.1084/jem.20190860.

 

Machado D et al. Polarization of microbial communities between competitive and cooperative metabolism. (2020) doi: 10.1101/2020.01.28.922583

 

Liu K, Lin L, Li Q, Xue Y, Zheng F, Wang F, Zheng C, Du L, Hu M, Huang Y, Shao C, Kong X, Melino G, Shi Y, and Wang Y. Scd1 controls de novo beige fat biogenesis through succinate-dependent regulation of mitochondrial complex II. PNAS February 4, 2020 117 (5) 2462-2472; first published January 17, 2020

 

Maier L et al. Dissecting the collateral damage of antibiotics on gut microbes. (2020) doi: 10.1101/2020.01.09.893560

 

Selley and Schuster et al. Brake dust exposure exacerbates inflammation and transiently compromises phagocytosis in macrophages. (2020) Metallomics.

 

Collins A, Miles GJ, Wood J, Pritchard C, MacFarlane M, Moss E. Patient-derived explants, xenografts and organoids: 3-dimensional patient-relevant pre-clinical models in endometrial cancer. Gynecol Oncol. 2020 Jan;156(1):251-259. doi: 10.1016/j.ygyno.2019.11.020. Epub 2019 Nov 22. Review.

 

Nicolai S, Mahen R, Raschellà G, Marini A, Pieraccioli M, Malewicz M, Venkitaraman AR, Melino G. ZNF281 is recruited on DNA breaks to facilitate DNA repair by non-homologous end joining. Oncogene. 2020 Jan;39(4):754-766. doi: 10.1038/s41388-019-1028-7. Epub 2019 Sep 30. PMID: 31570788

 

Nicolai S, Mahen R, Raschellà G, Marini A, Pieraccioli M, Malewicz M, Venkitaraman AR, Melino G. Clarifying the function of p73, the p53 homologous, in DNA Damage Response. ZNF281 is recruited on DNA breaks to facilitate DNA repair by non-homologous end joining. Oncogene. 2020 Jan;39(4):754-766. doi: 10.1038/s41388-019-1028-7. Epub 2019 Sep 30. PMID: 31570788

Elena Campione et al. Skin immunity and its dysregulation in atopic dermatitis, hidradenitis suppurativa and vitiligo.  Cell Cycle. Published online: 05 Jan 2020.

 

Oatley M, Bölükbası ÖV, Svensson V, Shvartsman M, Ganter K, Zirngibl K, Pavlovich PV, Milchevskaya V, Foteva V, Natarajan KN, Baying B, Benes V, Patil KR, Teichmann SA, Lancrin C. Single-cell transcriptomics identifies CD44 as a new marker and regulator of haematopoietic stem cells development.  Nat Commun 11(1) doi: 10.1038/s41467-019-14171-5 (2020)

Lieven et al. Memote: A community-driven effort towards a standardized genome-scale metabolic model test suite. Nature Biotechnol. In press (2020)

 

Waldron JA, Tack DC, Ritchey LE, Gillen SL, Wilczynska A, Turro E, Bevilacqua PC, Assmann SM, Bushell M, Le Quesne J. mRNA structural elements immediately upstream of the start codon dictate dependence upon eIF4A helicase activity. Genome Biol. 2019 Dec 30;20(1):300. doi: 10.1186/s13059-019-1901-2.PMID: 31888698 Free PMC article.

Liko D, Mitchell L, Campbell KJ, Ridgway RA, Jones C, Dudek K, King A, Bryson S, Stevenson D, Blyth K, Strathdee D, Morton JP, Bird TG, Knight JRP, Willis AE, Sansom OJ. Brf1 loss and not overexpression disrupts tissues homeostasis in the intestine, liver and pancreas. Cell Death Differ. 2019 Dec;26(12):2535-2550. doi: 10.1038/s41418-019-0316-7. Epub 2019 Mar 11. PMID: 30858608

 

Harvey RF, Pöyry TAA, Stoneley M, Willis AE. Signaling from mTOR to eIF2α mediates cell migration in response to the chemotherapeutic doxorubicin. Sci Signal. 2019 Dec 17;12(612). pii: eaaw6763. doi: 10.1126/scisignal.aaw6763. PMID:31848319

 

Al Dujaily E, Baena J, Das M, Sereno M, Smith C, Kamata T, Officer L, Pritchard C, Le Quesne J. Reduced Protumorigenic Tumor-Associated Macrophages With Statin Use in Premalignant Human Lung Adenocarcinoma. JNCI Cancer Spectr. 2019 Dec 13;4(2):pkz101. doi: 10.1093/jncics/pkz101. eCollection 2020 Apr.PMID: 32190817 Free PMC article.

 

Pitolli C, Wang Y, Mancini M, Shi Y, Melino G, Amelio I. Do Mutations Turn p53 into an Oncogene? Int J Mol Sci. 2019;20(24):6241. Published 2019 Dec 11. doi:10.3390/ijms20246241

 

Pitolli C, Wang Y, Candi E, Shi Y, Melino G, Amelio I. p53-Mediated Tumor Suppression: DNA-Damage Response and Alternative Mechanisms. Cancers (Basel). 2019;11(12):1983. Published 2019 Dec 9. doi:10.3390/cancers11121983

 

Wilczynska A, Gillen SL, Schmidt T, Meijer HA, Jukes-Jones R, Langlais C, Kopra K, Lu WT, Godfrey JD, Hawley BR, Hodge K, Zanivan S, Cain K, Le Quesne J, Bushell M. eIF4A2 drives repression of translation at initiation by Ccr4-Not through purine-rich motifs in the 5'UTR. Genome Biol. 2019 Dec 2;20(1):262. doi: 10.1186/s13059-019-1857-2.PMID: 31791371 Free PMC article. 

 

Antonova A, Hummel B, Khavaran A, Redhaber DM, Aprile-Garcia F, Rawat P, Gundel K, Schneck M, Hansen EC, Mitschke J, Mittler G, Miething C, Sawarkar R. Heat-Shock Protein 90 Controls the Expression of Cell-Cycle Genes by Stabilizing Metazoan-Specific Host-Cell Factor HCFC1. (2019) Cell Reports. 2019 Nov 5;29(6):1645-1659.e9. doi: 10.1016/j.celrep.2019.09.084.

 

Bernassola F, Chillemi G, Melino G. HECT-Type E3 Ubiquitin Ligases in Cancer.

Trends Biochem Sci. 2019;44(12):1057–1075. doi:10.1016/j.tibs.2019.08.004

 

Artem Smirnov, Lucia Anemona, Flavia Novelli, Cristina M. Piro, Margherita Annicchiarico-Petruzzelli, Gerry Melino and Eleonora Candi,*Smirnov et al. p63 Is a Promising Marker in the Diagnosis of Unusual Skin Cancer. Int. J. Mol. Sci. 2019, 20(22), 5781.

 

Millership SJ, Van de Pette M, Withers DJ.. Genomic imprinting and its effects on postnatal growth and adult metabolism. Cell Mol Life Sci. 2019 Oct;76(20):4009-4021. doi: 10.1007/s00018-019-03197-z. Epub 2019 Jul 3.

 

Pentimalli F, Grelli S, Di Daniele N, Melino G, Amelio I. Cell death pathologies: targeting death pathways and the immune system for cancer therapy. Genes Immun. 2019 Sep;20(7):539-554. doi: 10.1038/s41435-018-0052-x. Epub 2018 Dec 19. Review. PMID: 30563970

 

Balistreri CR, Garagnani P, Madonna R, Vaiserman A, Melino G. Developmental programming of adult haematopoiesis system. Ageing Res Rev. 2019 Sep;54:100918. doi: 10.1016/j.arr.2019.100918. Epub 2019 Jun 19. Review. PMID: 31226498

 

Spencer S, Köstel Bal S, Egner W, Lango Allen H, Raza SI, Ma CA, Gürel M, Zhang Y, Sun G, Sabroe RA, Greene D, Rae W, Shahin T, Kania K, Ardy RC, Thian M, Staples E, Pecchia-Bekkum A, Worrall WPM, Stephens J, Brown M, Tuna S, York M, Shackley F, Kerrin D, Sargur R, Condliffe A, Tipu HN, Kuehn HS, Rosenzweig SD, Turro E, Tavaré S, Thrasher AJ, Jodrell DI, Smith KGC, Boztug K, Milner JD, Thaventhiran JED. Loss of the interleukin-6 receptor causes immunodeficiency, atopy, and abnormal inflammatory responses. J Exp Med. 2019 Sep 2;216(9):1986-1998. doi: 10.1084/jem.20190344. Epub 2019 Jun 24.

 

Fercoq F, Remion E, Frohberger SJ, Vallarino-Lhermitte N, Hoerauf A, Le Quesne J, Landmann F, Hübner MP, Carlin LM, Martin C. IL-4 receptor dependent expansion of lung CD169+ macrophages in microfilaria-driven inflammation. PLoS Negl Trop Dis. 2019 Aug 30;13(8):e0007691. doi: 10.1371/journal.pntd.0007691. eCollection 2019 Aug.PMID: 31469835 Free PMC article.

 

Lawless D, Lango Allen H, Thaventhiran J; NIHR BioResource–Rare Diseases Consortium, Hodel F, Anwar R, Fellay J, Walter JE, Savic S. Predicting the Occurrence of Variants in RAG1 and RAG2. J Clin Immunol. 2019 Oct;39(7):688-701. doi: 10.1007/s10875-019-00670-z. Epub 2019 Aug 6. PMID:31388879

 

Melino G, Cecconi F, Pelicci PG, Mak TW, Bernassola F. Emerging roles of HECT-type E3 ubiquitin ligases in autophagy regulation.  Mol Oncol. 2019;13(10):2033–2048. doi:10.1002/1878-0261.12567

 

Terrinoni A, Palombo R, Pitolli C, Caporali S, De Berardinis R, Ciccarone S, Lanzillotta A, Mauramati S, Porta G, Minieri M, Melino G, Bernardini S, Bruno E. Role of the TAp63 Isoform in Recurrent Nasal Polyps. Folia Biol (Praha). 2019;65(4):170-180.PMID: 31903890

 

Bufalieri F, Infante P, Bernardi F, Caimano M, Romania P, Moretti M, Lospinoso Severini L, Talbot J, Melaiu O, Tanori M, Di Magno L, Bellavia D, Capalbo C, Puget S, De Smaele E, Canettieri G, Guardavaccaro D, Busino L, Peschiaroli A, Pazzaglia S, Giannini G, Melino G, Locatelli F, Gulino A, Ayrault O, Fruci D, Di Marcotullio L. ERAP1 promotes Hedgehog-dependent tumorigenesis by controlling USP47-mediated degradation of βTrCP. Nat Commun. 2019 Jul 24;10(1):3304. doi: 10.1038/s41467-019-11093-0. PMID: 31341163

 

Bykov YS, Cohen N, Gabrielli N, Manenschijn H, Welsch S, Chlanda P, Kukulski W, Patil KR, Schuldiner M, Briggs JAG. High-throughput ultrastructure screening using electron microscopy and fluorescent barcoding.  J Cell Biol. 218 (8): 2797 (2019)

 

Melkonian C, Gottstein W, Blasche S, Kim Y, Abel-Kistrup M, Swiegers H, Saerens S, Edwards N, Patil KR, Teusink B, Molenaar D. Finding functional differences between species in a microbial community: case studies in wine fermentation and kefir culture. Front Microbiol 10 doi: 10.3389/fmicb.2019.01347 (2019)

 

Gkatza NA, Castro C, Harvey RF, Heiß M, Popis MC, Blanco S, Bornelöv S, Sajini AA, Gleeson JG, Griffin JL, West JA, Kellner S, Willis AE, Dietmann S, Frye M. Cytosine-5 RNA methylation links protein synthesis to cell metabolism.  PLoS Biol. 2019 Jun 14;17(6):e3000297. doi: 10.1371/journal.pbio.3000297. eCollection 2019 Jun. PMID: 31199786

 

Queiroz RML, Smith T, Villanueva E, Marti-Solano M, Monti M, Pizzinga M, Mirea DM, Ramakrishna M, Harvey RF, Dezi V, Thomas GH, Willis AE, Lilley KS. Author Correction: Comprehensive identification of RNA-protein interactions in any organism using orthogonal organic phase separation (OOPS). Nat Biotechnol. 2019 Jun;37(6):692. doi: 10.1038/s41587-019-0161-8.  PMID: 31123356

 

Chen T, Sun X-M, Wu L. High Time for Complete Ban on Asbestos Use in Developing Countries. JAMA Oncol. 2019 Jun 1;5(6):779-780. doi: 10.1001/jamaoncol.2019.0446.

 

Chandramouli B, Melino G, Chillemi G. Smyd2 conformational changes in response to p53 binding: role of the C-terminal domain.  Mol Oncol. 2019 Jun; 13(6): 1450–1461. Published online 2019 May 21. doi: 10.1002/1878-0261.12502

 

Zhang Z, Gothe F, Pennamen P, James JR, McDonald D, Mata CP, Modis Y, Alazami AM, Acres M, Haller W, Bowen C, Döffinger R, Sinclair J, Brothers S, Zhang Y, Matthews HF, Naudion S, Pelluard F, Alajlan H, Yamazaki Y, Notarangelo LD, Thaventhiran JE, Engelhardt KR, Al-Mousa H, Hambleton S, Rooryck C, Smith KGC, Lenardo MJ. Human interleukin-2 receptor β mutations associated with defects in immunity and peripheral tolerance. J Exp Med. 2019 Jun 3;216(6):1311-1327. doi: 10.1084/jem.20182304. Epub 2019 Apr 30. PMID:31040185

 

Tuijnenburg P, Lango Allen H, de Bree GJ, Savic S, Jansen MH, Stockdale C, Simeoni I, Ten Berge IJM, van Leeuwen EMM; NIHR BioResource, Thaventhiran JE, Kuijpers TW. Pathogenic NFKB2 variant in the ankyrin repeat domain (R635X) causes a variable antibody deficiency. Clin Immunol. 2019 Jun;203:23-27. doi: 10.1016/j.clim.2019.03.010. Epub 2019 Apr 3. PMID:30953794

 

Gatti V, Bongiorno-Borbone L, Fierro C, Annicchiarico-Petruzzelli M, Melino G, Peschiaroli A. p63 at the Crossroads between Stemness and Metastasis in Breast Cancer. Int J Mol Sci. 2019 May 31;20(11). pii: E2683. doi: 10.3390/ijms20112683. Review. PMID: 31159154

 

Palombo R, Caporali S, Falconi M, Iacovelli F, Morozzo Della Rocca B, Lo Surdo A, Campione E, Candi E, Melino G, Bernardini S, Terrinoni A. Luteolin-7-O-β-d-Glucoside Inhibits Cellular Energy Production Interacting with HEK2 in Keratinocytes. Int J Mol Sci. 2019 May 31;20(11). pii: E2689. doi: 10.3390/ijms20112689. PMID: 31159225

 

Wei W, Tuna S, Keogh MJ, Smith KR, Aitman TJ, Beales PL, Bennett DL, Gale DP, Bitner-Glindzicz MAK, Black GC, Brennan P, Elliott P, Flinter FA, Floto RA, Houlden H, Irving M, Koziell A, Maher ER, Markus HS, Morrell NW, Newman WG, Roberts I, Sayer JA, Smith KGC, Taylor JC, Watkins H, Webster AR, Wilkie AOM, Williamson C; NIHR BioResource–Rare Diseases; 100,000 Genomes Project–Rare Diseases Pilot, Ashford S, Penkett CJ, Stirrups KE, Rendon A, Ouwehand WH, Bradley JR, Raymond FL, Caulfield M, Turro E, Chinnery PF. Germline selection shapes human mitochondrial DNA diversity. Science. 2019 May 24;364(6442). pii: eaau6520. doi: 10.1126/science.aau6520. Epub 2019 May 23. PMID:31123110

 

Gatti V, Fierro C, Annicchiarico‐Petruzzelli M, Melino G, Peschiaroli A. ΔNp63 in squamous cell carcinoma: defining the oncogenic routes affecting epigenetic landscape and tumour microenvironment. Mol Oncol. 2019 May; 13(5): 981–1001. Published online 2019 Mar 22. doi: 10.1002/1878-0261.12473

 

Moore, D.A, Sereno, M, Das, M, Acevedo, J.D.B, Sinnadurai, S, Smith, C, McSweeney, A, Su, X, Officer, L, Jones, C, Dudek, K, Guttery, D, Taniere, P. Spriggs, R.V. Le Quesne, J. In situ growth in early lung adenocarcinoma may represent precursor growth or invasive clone outgrowth – a clinically relevant distinction. (April 2019). Modern Pathology, 32(8), 1095-1105.

 

Gorman KM, Meyer E, Grozeva D, Spinelli E, McTague A, Sanchis-Juan A, Carss KJ, Bryant E, Reich A, Schneider AL, Pressler RM, Simpson MA, Debelle GD, Wassmer E, Morton J, Sieciechowicz D, Jan-Kamsteeg E, Paciorkowski AR, King MD, Cross JH, Poduri A, Mefford HC, Scheffer IE, Haack TB, McCullagh G; Deciphering Developmental Disorders Study; UK10K Consortium; NIHR BioResource, Millichap JJ, Carvill GL, Clayton-Smith J, Maher ER, Raymond FL, Kurian MA. Bi-allelic Loss-of-Function CACNA1B Mutations in Progressive Epilepsy-Dyskinesia. Am J Hum Genet. 2019 May 2;104(5):948-956. doi: 10.1016/j.ajhg.2019.03.005. Epub 2019 Apr 11. PMID:30982612

 

Fedorova O, Petukhov A, Daks A, Shuvalov O, Leonova T, Vasileva E, Aksenov N, Melino G, Barlev NA. Orphan receptor NR4A3 is a novel target of p53 that contributes to apoptosis Oncogene. 2019 Mar ;38(12):2108-2122. doi: 10.1038/s41388-018-0566-8. Epub 2018 Nov 19.

 

Smirnov A, Lena AM, Cappello A, Panatta E, Anemona L, Bischetti S, Annicchiarico-Petruzzelli M, Mauriello A, Melino G, Candi E. ZNF185 is a p63 target gene critical for epidermal differentiation and squamous cell carcinoma development. Oncogene. 2019 Mar;38(10):1625-1638. doi: 10.1038/s41388-018-0509-4.

 

Aprile-Garcia F, Tomar P, Hummel B, Khavaran A and Sawarkar R. Nascent-protein ubiquitination is required for heat-shock induced gene downregulation. (2019) Nature Structural and Molecular Biology. 26(2):137-146.

 

Bhattacharya S, Serror L, Nir E, Dhiraj D, Altshuler A, Khreish M, Tiosano B, Hasson P, Panman . Luxenburg C, Aberdam D, Shalom-Feuerstein R. SOX2 regulates P63 and stem/progenitor cell state in the corneal epithelium. (2019). Stem Cells 37(3):417-429

 

Vassileva V, Stribbling SM, Barnes C, Carroll L, Braga M, Abrahams J, Heinzmann K, Haegeman C, Simpson KL, MacFarlane M, Dive C, Honeychurch J, Illidge TM, Aboagye EO. Evaluation of apoptosis imaging biomarkers in a genetic model of cell death. EJNMMI Res. 2019 9(1):18. doi: 10.1186/s13550-019-0487-8.

 

Queiroz RML, Smith T, Villanueva E, Marti-Solano M, Monti M, Pizzinga M, Mirea DM, Ramakrishna M, Harvey RF, Dezi V, Thomas GH, Willis AE, Lilley KS. Comprehensive identification of RNA-protein interactions in any organism using orthogonal organic phase separation (OOPS). Nat Biotechnol. 2019 Feb;37(2):169-178. doi: 10.1038/s41587-018-0001-2. Epub 2019 Jan 3. Erratum in: Nat Biotechnol. 2019 Jun;37(6):692.  PMID: 30607034

 

Raschellà G, Melino G, Gambacurta A. Cell death in cancer in the era of precision medicine. Genes Immun. 2019;20(7):529–538. doi:10.1038/s41435-018-0048-6

 

Buffa et al. Biomarkers for vascular ageing in aorta tissues and blood samples Exp Gerontol 2019. 128: 110741.

 

Smirnov et al. Transglutaminase 3 is expressed in basal cell carcinoma of the skin. Eur J Dermatol 2019. 29 (5), 477-483. 

 

Huang et al. Single cell transcriptomic analysis of human mesenchymal stem cells reveals limited heterogeneity. Cell Death Dis. 2019; 10(5):368.

 

Orienti et al. A new bioavailable fenretinide formulation with antiproliferative, antimetabolic, and cytotoxic effects on solid tumors. Cell Death Dis. 2019; 10(7):529.

 

Carbone & Melino. Stearoyl CoA Desaturase Regulates Ferroptosis in Ovarian Cancer Offering New Therapeutic Perspectives.  Cancer Res 2019. 79 (20), 5149-5150.

 

Carbone & Melino. Lipid metabolism offers anticancer treatment by regulating ferroptosis. Cell Death Differ. 2019. 26 (12), 2516-2519.   

 

Strappazzon et al. Correction to: HUWE1 controls MCL1 stability to unleash AMBRA1-induced mitophagy. Cell Death Differ 2019.  

 

Lanna et al. Skin immunity and its dysregulation in psoriasis. Cell Cycle 2019. 18 (20), 2581-2589. 

 

Michaletti et al. Multi-omics profiling of calcium-induced human keratinocytes differentiation reveals modulation of unfolded protein response signaling pathways.  Cell Cycle 2019. 18 (17), 2124-2140. 

 

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