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MRC Toxicology Unit

 

 

Biasci D, Lee JC, Noor NM, et al.  'A blood-based prognostic biomarker in IBD Gut.' doi: 10.1136/gutjnl-2019-318343. Epub 2019 Apr 27. PMID: 31030191

 

Lawless D, Lango Allen H, Thaventhiran J; NIHR BioResource–Rare Diseases Consortium, Hodel F, Anwar R, Fellay J, Walter JE, Savic S. ‘Predicting the Occurrence of Variants in RAG1 and RAG2.’ J Clin Immunol. 2019 Aug 6. doi: 10.1007/s10875-019-00670-z. [Epub ahead of print]. PMID: 31388879

 

Spencer S, Köstel Bal S, Egner W, Lango Allen H, Raza SI, Ma CA, Gürel M, Zhang Y, Sun G, Sabroe RA, Greene D, Rae W, Shahin T, Kania K, Ardy RC, Thian M, Staples E, Pecchia-Bekkum A, Worrall WPM, Stephens J, Brown M, Tuna S, York M, Shackley F, Kerrin D, Sargur R, Condliffe A, Tipu HN, Kuehn HS, Rosenzweig SD, Turro E, Tavaré S, Thrasher AJ, Jodrell DI, Smith KGC, Boztug K, Milner JD, Thaventhiran JED. ‘Loss of the interleukin-6 receptor causes immunodeficiency, atopy, and abnormal inflammatory responses.’ J Exp Med. 2019 Sep 2;216(9):1986-1998. doi: 10.1084/jem.20190344. Epub 2019 Jun 24. PMID: 31235509

 

Zhang Z, Gothe F, Pennamen P, James JR, McDonald D, Mata CP, Modis Y, Alazami AM, Acres M, Haller W, Bowen C, Döffinger R, Sinclair J, Brothers S, Zhang Y, Matthews HF, Naudion S, Pelluard F, Alajlan H, Yamazaki Y, Notarangelo LD, Thaventhiran JE, Engelhardt KR, Al-Mousa H, Hambleton S, Rooryck C, Smith KGC, Lenardo MJ. ‘Human interleukin-2 receptor β mutations associated with defects in immunity and peripheral tolerance.’ J Exp Med. 2019 Jun 3;216(6):1311-1327. doi: 10.1084/jem.20182304. Epub 2019 Apr 30. PMID: 31040185

 

Tuijnenburg P, Lango Allen H, de Bree GJ, Savic S, Jansen MH, Stockdale C, Simeoni I, Ten Berge IJM, van Leeuwen EMM; NIHR BioResource, Thaventhiran JE, Kuijpers TW.‘Pathogenic NFKB2 variant in the ankyrin repeat domain (R635X) causes a variable antibody deficiency.’ Clin Immunol. 2019 Jun; 203:23-27. doi: 10.1016/j.clim.2019.03.010. Epub 2019 Apr 3. PMID: 30953794

 

Moore DM, Sereno M, Das M, Acevedo JDB, Sinnadurai S, Smith C, McSweeney A, Su X, Officer L, Jones C, Dudek K, Guttery D, Taniere P, Spriggs RV, Le Quesne J. ‘In situ growth in early lung adenocarcinoma may represent precursor growth or invasive clone outgrowth – a clinically relevant distinction’.  Modern Pathology, accepted 28 March 2019.

 

Martins L, Loh S, Garrido-Maraver J, Celardo I. ‘Enhancing folic acid metabolism suppresses defects associated with loss of Drosophila mitofusin’. Cell Death and Disease https://doi.org/10.17863/CAM.37286.

 

Pizzinga M, Bates C, Lui J, Forte G, Morales-Polanco F, Linney E, Knotkova B, Wilson B, Solari CA, Berchowitz LE, Portela P, Ashe MP. ‘Translation factor mRNA granules direct protein synthetic capacity to regions of polarized growth’.Mariavittoria Pizzinga  Journal of Cell Biology. Published March 15, 2019. DOI: 10.1083/jcb.201704019.

 

Liko D, Mitchell L, Campbell KJ, Ridgway RA, Jones C, Dudek K, King A, Bryson S, Stevenson D, Blyth K, Strathdee D, Morton JP, Bird TG, Knight JRP, Willis AE, Sansom OJ. ‘Brf1 loss and not overexpression disrupts tissues homeostasis in the intestine, liver and pancreas’. Cell Death Differ. 2019 Mar 11. doi: 10.1038/s41418-019-0316-7. [Epub ahead of print] PubMed PMID: 30858608.

 

Skalka G, Hall H, Somers J, Bushell M, Willis AE and Malewicz M.  ‘Leucine zipper and ICAT domain containing (LZIC) protein regulates cell cycle transitions in response to ionising radiation’. Cell Cycle, March 2019.

 

Munnur D, Somers J, Skalka G, Weston R, Jukes-Jones R, Bhogadia M, Dominguez C, Cain K, Ahel I, Malewicz M‘NR4A Nuclear Receptors Target Poly-ADP-Ribosylated DNA-PKcs Protein to Promote DNA Repair’.  Cell Reports, 19 February 2019. 26(8):P2028 https://doi.org/10.1016/j.celrep.2019.01.083.

 

Vassileva V, Stribbling SM, Barnes C, Carroll L, Braga M, Abrahams J, Heinzmann K, Haegeman C, Simpson KL, MacFarlane M, Dive C, Honeychurch J, Illidge TM, Aboagye EO.  Evaluation of apoptosis imaging biomarkers in a genetic model of cell death. EJNMMI Res. 2019 Feb 19;9(1):18. doi: 10.1186/s13550-019-0487-8.

 

Rakhit CP, Trigg RM, Le Quesne J, Kelly M, Shaw JA, Pritchard C, Martins LM.  ‘Early detection of pre-malignant lesions in a KRASG12D-driven mouse lung cancer model by monitoring circulating free DNA’.  Disease Models & Mechanisms 2019.  12:  dmm036863  doi: 10.1242/dmm.036863  Published 12 February 2019.

 

Bhattacharya S, Serror L, Nir E, Dhiraj D, Altshuler A, Khreish M, Tiosano B, Hasson P, Panman L, Luxenburg C, Aberdam D, Shalom-Feuerstein R.  ‘SOX2 Regulates P63 and Stem/Progenitor Cell State in the Corneal Epithelium’. Stem Cells. 2019 Mar;37(3):417-429. doi: 10.1002/stem.2959. Epub 2019 Feb 1.

 

Selley L, Phillips DH, Mudway I. ‘The potential of omics approaches to elucidate mechanisms of biodiesel-induced pulmonary toxicity’.  Particle and Fibre Toxicology. (2019) 16:4.  https://doi.org/10.1186/s12989-018-0284-y.

 

Queiroz RML, Smith T,  Villanueva E,  Marti-Solano M, Monti M, Pizzinga M, Mirea DM, Ramakrishna M, Harvey RF,  Dezi V, Thomas GH, Willis AE, Lilley KS.  ‘Comprehensive identification of RNA–protein interactions in any organism using orthogonal organic phase separation (OOPS)’ Nature Biotechnology vol 37, pages169–178 (3 Jan 2019).

 

Pentimalli F, Grelli S, Di Daniele N, Melino G, Amelio I. ‘Cell death pathologies: targeting death pathways and the immune system for cancer therapy’.  Genes Immun. 2018 Dec 19. doi: 10.1038/s41435-018-0052-x. [Epub ahead of print] Review. PMID: 30563970

 

Lopriore P, Capitanio N, Panatta E, Di Daniele N, Gambacurta A, Melino G, Amelio I. ‘TAp73 regulates ATP7A: possible implications for ageing-related diseases’.  Aging (Albany NY). 2018 Dec 8;10(12):3745-3760. doi: 10.18632/aging.101669. PMID: 30530920

 

Rotblat B, Agostini M, Niklison-Chirou MV, Amelio I, Willis AE, Melino G. ‘Sustained protein synthesis and reduced eEF2K levels in TAp73(-\-) mice brain: a possible compensatory mechanism’. Cell Cycle. 2018;17(23):2637-2643. doi: 10.1080/15384101.2018.1553341. Epub 2018 Dec 4. PubMed PMID: 30507330; PubMed Central PMCID: PMC6300112.

 

Piñeiro D, Stoneley M, Ramakrishna M, Alexandrova J, Dezi V, Juke-Jones R, Lilley KS, Cain K, Willis AE.  ‘Identification of the RNA polymerase I-RNA interactome’. Nucleic Acids Res. 2018 Nov 16;46(20):11002-11013. doi: 10.1093/nar/gky779. PubMed PMID: 30169671; PubMed Central PMCID: PMC6237751.

 

Amelio I, Mancini M, Petrova V, Cairns RA, Vikhreva P, Nicolai S, Marini A, Antonov AA, Le Quesne J, Baena Acevedo JD, Dudek K, Sozzi G, Pastorino U, Knight RA, Mak TW, Melino G. ‘p53 mutants cooperate with HIF-1 in transcriptional regulation of extracellular matrix components to promote tumor progression’.  Proc Natl Acad Sci U S A. 2018 Nov 13;115(46):E10869-E10878. doi: 10.1073/pnas.1808314115. Epub 2018 Oct 31. PMID: 30381462

 

Raschellà G, Melino G, Gambacurta A.’Cell death in cancer in the era of precision medicine’. Genes Immun. 2018 Oct 19. doi: 10.1038/s41435-018-0048-6. [Epub ahead of print] Review.

 

Smirnov A, Lena AM, Cappello A, Panatta E, Anemona L, Bischetti S, Annicchiarico-Petruzzelli M, Mauriello A, Melino G, Candi E. ‘ZNF185 is a p63 target gene critical for epidermal differentiation and squamous cell carcinoma development.’  Oncogene. 2018 Oct 18. doi: 10.1038/s41388-018-0509-4. [Epub ahead of print]

 

Carbone M, Amelio I, Affar EB, Brugarolas J, Cannon-Albright LA, Cantley LC, Cavenee WK, Chen Z, Croce CM, Andrea A, Gandara D, Giorgi C, Jia W, Lan Q, Mak TW, Manley JL, Mikoshiba K, Onuchic JN, Pass HI, Pinton P, Prives C, Rothman N, Sebti SM, Turkson J, Wu X, Yang H, Yu H, Melino G.  ‘Consensus report of the 8 and 9th Weinman Symposia on Gene x Environment Interaction in carcinogenesis: novel opportunities for precision medicine’.  Cell Death Differ. 2018 Nov;25(11):1885-1904. doi: 10.1038/s41418-018-0213-5. Epub 2018 Oct 15.  PMID: 30323273

 

Craxton A, Munnur D, Jukes-Jones R, Skalka G, Langlais C, Cain K, & Malewicz M Z.  ‘PAXX and its paralogues synergistically direct DNA polymerase λ activity in DNA repair.’  Nature Communications, 24 September 2018. 9 (3877) https://doi.org/10.1038/s41467-018-06127-y

 

Di Rita A, Peschiaroli A, D Acunzo P, Strobbe D, Hu Z, Gruber J, Nygaard M, Lambrughi M, Melino G, Papaleo E, Dengjel J, El Alaoui S, Campanella M, Dötsch V, Rogov VV, Strappazzon F, Cecconi F. ‘HUWE1 E3 ligase promotes PINK1/PARKIN-independent mitophagy by regulating AMBRA1 activation via IKKα’.  Nat Commun. 2018 Sep 14;9(1):3755. doi: 10.1038/s41467-018-05722-3.

 

Felley-Bosco E, MacFarlane M. ‘Asbestos: Modern Insights for Toxicology in the Era of Engineered Nanomaterials’. Chem Res Toxicol. 2018 Oct 15;31(10):994-1008. doi: 10.1021/acs.chemrestox.8b00146. Epub 2018 Sep 12. PMID: 30156102

 

Fedorova O, Daks A, Petrova V, Petukhov A, Lezina L, Shuvalov O, Davidovich P, Kriger D, Lomert E, Tentler D, Kartsev V, Uyanik B, Tribulovich V, Demidov O, Melino G, Barlev NA. ‘Novel isatin-derived molecules activate p53 via interference with Mdm2 to promote apoptosis’. Cell Cycle. 2018;17(15):1917-1930. doi: 10.1080/15384101.2018.1506664. Epub 2018 Sep 5.

 

Titov A, Petukhov A, Staliarova A, Motorin D, Bulatov E, Shuvalov O, Soond SM, Piacentini M, Melino G, Zaritskey A, Barlev NA. The biological basis and clinical symptoms of CAR-T therapy-associated toxicites.  Cell Death Dis. 2018 Sep 4;9(9):897. doi: 10.1038/s41419-018-0918-x.

 

Gatti V, Fierro C, Compagnone M, Giangrazi F, Markert EK, Bongiorno-Borbone L, Melino G, Peschiaroli A.’ΔNp63 regulates the expression of hyaluronic acid-related genes in breast cancer cells.’  Oncogenesis. 2018 Aug 24;7(8):65. doi: 10.1038/s41389-018-0073-3.

 

Lezina L, Spriggs RV, Beck D, Jones C, Dudek KM, Bzura A, Jones GDD, Packham G,
Willis AE, Wagner SD. ‘CD40L/IL-4-stimulated CLL demonstrates variation in translational regulation of DNA damage response genes including ATM’. Blood Adv.  2018 Aug 14;2(15):1869-1881. doi: 10.1182/bloodadvances.2017015560. PubMed PMID: 30082430; PubMed Central PMCID: PMC6093746.

 

Amelio I, Melino G.  ‘Similar Domains for Different Regulations of p53 Family’.  Structure. 2018 Aug 7;26(8):1047-1049. doi: 10.1016/j.str.2018.07.003.

 

Kruspig B, Monteverde T, Neidler S, Hock A, Kerr E, Nixon C, Clark W, Hedley A, Laing S, Coffelt SB, Le Quesne J, Dick C, Vousden K, Martins CP, Murphy DJ. ‘The ERBB network facilitates KRAS-driven lung tumorigenesis’. Science Translational Medicine, 2018, Vol 10(446).

 

Lazarus KA, Hadi F, Zambon E, Bach K, Santolla M-F, Watson JK, Correia LL, Das M, Ugur R, Pensa S, Becker L, Campos LS, Ladds G, Pentao L, Evan G, McCaughan F, Le Quesne J, Lee J-H, Calado D, Khaled WT. ‘BCL11A interacts with SOX2 to control the expression of epigenetic regulators in lung squamous cell carcinoma’.  Nature Communications, 2018, Vol 9(1) 3327.