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MRC Toxicology Unit

 

Current Vacancies:

 

MRC Postdoctoral Fellow
Research Associate Level, Grade 7 (£32,816-£40,322)
Closing Date: Sunday 3rd November
Reference: PU20843
We are looking to appoint an MRC Postdoctoral Fellow (PF) to join Mathew Van de Pette's newly established lab "Epigenetic Mechanisms of Toxicity." We will employ multi-disciplinary approaches, including in vivo longitudinal imaging, genomics, metabolomics and development of novel in vitro and single cell approaches.

This is predominantly a bioinformatics role where you will be working on a project exploring links between developmental exposure to environmental and pharmacological agents, and their impact on the embryonic and post-natal epigenome. There will be a focus on differentiating between transient and life-long changes in gene expression and multi-generational heritability of these changes.

More details/ apply

 

MRC Postdoctoral Fellow
Research Associate Level, Grade 7 (£32,816-£40,322)
Closing Date: Sunday 3rd November
Reference: PU20844
We are looking to appoint an MRC Postdoctoral Fellow (PF) to join Mathew Van de Pette's newly established lab "Epigenetic Mechanisms of Toxicity." We will employ multi-disciplinary approaches, including in vivo longitudinal imaging, genomics, metabolomics and development of novel in vitro and single cell approaches.

You will work on a project exploring links between developmental exposure to pharmacological agents, either in isolation or in combination, and their impact on the developing offspring. You will explore potential phenotypes that are caused by the exposures, and monitor the extent of these changes. This project will use both wild type animals and a series of reporter mouse lines, that enable in vivo monitoring of an epigenetic state. There will be close overlap with other projects in the lab, which will require collaborative work between members. You will also have freedom to develop your own projects, in line with lab interests.

More details/ apply

 

MRC Postdoctoral Fellow
Research Associate Level, Grade 7 (£32,816-£40,322)
Closing Date: Wednesday 6th November
Reference: PU19151
We are seeking a highly-motivated postdoc candidate, to join Miguel Martins's lab. Our work employs Drosophila as a model organism to better understand the consequences of mitochondrial dysfunction for the activation of adverse outcome pathways that lead to cellular and tissue damage. We employ multi-disciplinary approaches, including Drosophila genetics, quantitative fly behaviour analysis, RNAseq, metabolomics, quantitative proteomics, and microbiome analysis. We model how drug exposure and mitochondrial liabilities activate adverse outcome pathways. These adverse outcome pathways, in turn lead to cellular and tissue dysfunction. 
More details/ apply

 

Research Assistant / Associate (Fixed-term)
Research Associate Grade 7 (£32,816-£40,322) or Research Assistant Grade 5 (£26,715 - £30,942)
Closing Date: Sunday 17th November
Reference: PU21026
We are looking to appoint a postdoctoral Research Associate to join James Thaventhiran’s team in an exciting research project to investigate the contribution of self-reactive lymphocytes to disease when immune checkpoints are deficient. The post will be ideal for a trained murine immunologist who is seeking experience in computational biology. However, talented candidates with a strong background in statistical methods or computational biology who are keen to develop experience in immunology are encouraged to apply.
More details/ apply