Dr Nobuhiro Morone

  • Senior Investigator Scientist and Facility Head
Dr Nobuhiro Morone

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About

Biography:

2015-Present Senior Investigator Scientist at MRC Toxicology Unit and visiting Professor at Kyoto University, Kyoto, Japan.

2010-2015 Senior Lecturer at iCeMS Kyoto University, Kyoto, Japan.

2005-2010 Section Chief at National Institute of Neuroscience, National Centre of Neurology and Psychiatry, Tokyo, Japan.

2004-2005 PI at Mitsubishi Kagaku Institute of Life Sciences, Tokyo, Japan.

1999-2003 Postdoctoral at ERATO-JST/Nagoya University, Nagoya, Japan.

1999 PhD (Kyoto University, Japan) Synthetic & Biological Chemistry.

 

Research Interests:

 Nobu’s research in the Unit is based on “EM-based nano-toxicology” for visual understanding the role of endocytosis at the plasma membrane and membrane recycling among the intracellular organelle compartments affected by toxins or drugs for mesothelioma in immune-oncology and neurogenerative diseases as well. Nobu’s EM covers a whole range of cellular tissues from the mouse brain to the signalling receptor-complexes by using both classic and advanced microscopy from deep-etch EM and cryo-EM (single particle analysis and tomography). Nobu’s future goal is to determine the atomic structure of crucial membrane machinery (caveolae with MSK) and chromatin complex in situ by the hybrid EM correlation, as well as to establish a lesion detection system under EM resolution by a template matching method toward tumour and neurogenerative diseases.

UK-Japan Structural Life Science Forum (Chair)

 

Publications

Selected publications

Capturing human trophoblast development with naive pluripotent stem cells in vitro Io S, Kabata M, Iemura Y, Semi K, Morone N, Minagawa A, Wang B, Okamoto I, Nakamura T, Kojima Y, Iwatani C, Tsuchiya H, Kaswandy B, Kondoh E, Kaneko S, Woltjen K, Saitou M, Yamamoto T, Mandai M, Takashima Y Cryo-EM structural analysis of FADD:Caspase-8 complexes defines the catalytic dimer architecture for co-ordinated control of cell fate Fox JL, Hughes MA, Meng X, Sarnowska NA, Powley IR, Jukes-Jones R, Dinsdale D, Ragan TJ, Fairall L, Schwabe JWR, Morone N, Cain K, MacFarlane M The C terminus of p73 is essential for hippocampal development Amelio I, Panatta E, Niklison-Chirou MV, Steinert JR, Agostini M, Morone N, Knight RA, Melino G Mechanism of crosstalk between the LSD1 demethylase and HDAC1 deacetylase in the CoREST complex Song Y, Dagil L, Fairall L, Robertson N, Wu M, Ragan TJ, Savva CG, Saleh A, Morone N, Kunze MBA, Jamieson AG, Cole PA, Hansen DF, Schwabe JWR Nitric oxide-mediated posttranslational modifications control neurotransmitter release by modulating complexin farnesylation and enhancing its clamping ability Robinson SW, Bourgognon JM, Spiers JG, Breda C, Campesan S, Butcher A, Mallucci GR, Dinsdale D, Morone N, Mistry R, Smith TM, Guerra-Martin M, Challiss RAJ, Giorgini F, Steinert JR Membrane re-modelling by BAR domain superfamily proteins via molecular and non-molecular factors Nishimura T, Morone N, Suetsugu S Hybrid Cellular Metabolism Coordinated by Zic3 and Esrrb Synergistically Enhances Induction of Naive Pluripotency Sone M, Morone N, Nakamura T, Tanaka A, Okita K, Woltjen K, Nakagawa M, Heuser JE, Yamada Y, Yamanaka S, Yamamoto T Confined diffusion of transmembrane proteins and lipids induced by the same actin meshwork lining the plasma membrane Fujiwara TK, Iwasawa K, Kalay Z, Tsunoyama TA, Watanabe Y, Umemura YM, Murakoshi H, Suzuki KG, Nemoto YL, Morone N, Kusumi A Development of a reentrant arrhythmia model in human pluripotent stem cell-derived cardiac cell sheets Kadota S, Minami I, Morone N, Heuser JE, Agladze K, Nakatsuji N Membrane mechanisms for signal transduction: the coupling of the meso-scale raft domains to membrane-skeleton-induced compartments and dynamic protein complexes Kusumi A, Fujiwara TK, Morone N, Yoshida KJ, Chadda R, Xie M, Kasai RS, Suzuki KG.