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Organisers:
Della David & Oliver Florey (Babraham Institute)
Laura Itzhaki & Ritwick Sawarkar (University of Cambridge).
Confirmed speakers:
- Rick Morimoto (Keynote speaker), Department of Molecular Biosciences, Northwestern University and Royal Society Wolfson Visiting Fellow at the University of Cambridge – The Proteostasis Network as a Biological Clock for Health, Aging and Disease
- Ivana Bjedov, Molecular Biology of Cancer Research Group, UCL Cancer Institute – Protein phase transitions
- Bernadette Carroll, School of Biochemistry, University of Bristol – Dysregulated proteostasis as a virulence mechanism of pathogenic bacteria, the case of the Mycobacterium ulcerans exotoxin mycolactone
- Pedro Carvalho, Sir William Dunn School of Pathology, University of Oxford – The challenges of predicting amyloidogenicity
- Benedict Cross, PhoreMost, Cambridge – Exploring lysosomal dysfunction in cellular senescence
- Tuomas Knowles, Department of Chemistry, University of Cambridge – How neuronal signalling connects perception with proteostasis and ageing
- Sheena Radford, Faculty of Biological Sciences, University of Leeds – Diverse ubiquitin chain topologies orchestrate plant immune signalling
- Rahul Samant, Babraham Institute, Cambridge – Induced control of protein degradation
- Steven Spoel, Institute of Molecular Plant Sciences, University of Edinburgh – Discovery and development of NXP800: a clinical stage GCN2/ISR activator that inhibits HSF1 transcription for the treatment of ARID1A mutant ovarian cancer
- Rachel Simmonds, Department of Microbial Sciences, University of Surrey – Increased fidelity of protein synthesis extends lifespan
- Rebecca Taylor, School of Biological Sciences, University of East Anglia – title to be confirmed
- Paul Workman, Signal Transduction & Molecular Pharmacology team, Institute of Cancer Research – Deconvoluting cellular proteostasis strategies across proliferative states
Panel discussion on day 2: How can our knowledge of proteostasis be translated into therapeutic benefit?
Chaired by Kathryn Chapman, Director, Science & Entrepreneurship at Babraham Research Campus
Panel:
- Paul Thompson, Chief Scientific Officer, Mission Therapeutics
- Fiona Menzies, Associate Vice President, Eli Lilly and Company
- James Hunt, R&D Biologics Engineering, AstraZeneca
- Wei-Li (William) Kuan, Head of Biology of the Alborada Drug Discovery Institute, University of Cambridge
- Ralph Minter, Senior Vice President Research, Alchemab
See the full programme and register at: www.ukproteostasis2024.eventbrite.co.uk
Registration closes on 24th April 2024.
Find out more about the UK Proteostasis Network: https://proteostasisuk.co.uk/