Biography:

Jose studied Biochemistry and Molecular Biology at the University of Murcia (Spain) where he also obtained his PhD on experimental haematology. He then continued his research on haematology in the US and UK where he has been leading multiple projects on the role of blood platelets in haemostasis, thrombosis, inflammation and cancer. More recently, Jose has focused on the secretory granules of platelets and other immune cells and their defects in a rare bleeding and immune disorder. He joined the Chapman group to lead oncology and immunology research programs where he is involved in the identification of new therapeutic targets for multiple myeloma and investigate their molecular and cellular function.

Outreach:

• Blog for the general audience: https://www.nhsbt.nhs.uk/research-and-development/rd-blog/no-beach-turns-platelets-grey-by-dr-jose-guerrero/
• Commentary on preprints: https://prelights.biologists.com/highlights/human-handedness-genetics-microtubules-neuropsychiatric-diseases-and-brain-language-areas/

Publications:

Complete publication list: https://scholar.google.com/citations?user=klFVSnwAAAAJ&hl=en

1. Sims MC, Mayer L, Collins JH,…., Guerrero JA. Novel manifestations of immune dysregulation and granule defects in gray platelet syndrome. Blood. 2020. (with Cover Art and inside commentary).

2. Mayer L, Jasztal M, Pardo M, …., Guerrero JA. Nbeal2, interacts with Dock7, Sec16a and Vac14. Blood. 2018. (with Cover Art and inside commentary).

3. Parsons ME, Szklanna PB, Guerrero JA, et al. Platelet releasate proteome profiling reveals a core set of proteins with low variance between healthy individuals. Proteomics. 2018.

4. Sowerby JM, Thomas DC, Clare S, Espéli M, Guerrero JA, et al. NBEAL2 is required for neutrophil and NK cell function and pathogen defense. Journal of Clinical Investigation. 2017.

5. Bariana TK, Ouwehand WH, Guerrero JA, Gomez K. Dawning of the age of genomics for platelet granule disorders: improving insight, diagnosis and management. British Journal of Haematology. 2017.

6. Guerrero JA, Bennett C, et al. Gray platelet syndrome: proinflammatory megakaryocytes and α-granule loss cause myelofibrosis and confer metastasis resistance in mice. Blood. 2014.