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MRC Toxicology Unit

 

Research

I am responsible for analysing all sequencing data, and the majority of microarray data, generated by the Unit.   I have a particular interest in methods for analysing ribosome profiling data.   I also collaborate with researchers within the Unit, and groups outside the Unit, to undertake many types of bioinformatic projects, including devising strategies, developing software, performing statistical analyses, and interpreting outcomes. 

Publications

Key publications: 

 

CD40L/IL-4–stimulated CLL demonstrates variation in translational regulation of DNA damage response genes including ATM

Lezina, L., Spriggs, R.V., Beck, D., Jones, C., Dudek, K.M., Bzura, A., Jones, G.D.D., Packham, G., Willis, A.E. & Wagner, S.D.

2018, Blood Advances, 2, 1869-1881.

 

An improved analysis methodology for translational profiling by microarray

Sbarrato, T., Spriggs, R.V., Wilson, L., Jones, C., Dudek, K., Bastide, A., Pichon, X., Pöyry, T. & Willis, A.E.

2017, RNA, 23, 1601-1613.

 

RTN3 is a novel cold-induced protein and mediates neuroprotective effects of RBM3

Bastide, A., Peretti, D., Knight, J.R.P., Grosso, S., Spriggs, R.V., Pichon, X., Sbarrato, T., Roobol, A., Roobol, J., Vito, D., Bushell, M., von der Haar, T., Smales, C.M., Mallucci, G.R., & Willis, A.E.

2017, Current Biology, 27(5), 638–650.

 

A ribosome related signature in peripheral blood CLL B cells is linked to reduced survival following treatment

Sbarrato, T., Horvilleur, E., Poyry, T., Hill, K., Chaplin, L.C., Spriggs, R.V., Stoneley, M., Wilson, L., Jayne, S., Vulliamy, T., Beck, D., Dokal, I., Dyer, M.J.S., Yeomans, A.M., Packham, G., Bushell, M., Wagner, S.D. & Willis, A.E.

2016, Cell Death and Disease, 7, e2249.

 

Temporal regulation of distinct internal ribosome entry sites of the dicistroviridae Cricket Paralysis virus.

Khong A, Bonderoff JM, Spriggs RV, Tammpere E, Kerr CH, Jackson TJ, Willis AE, Jan E.

Viruses. 2016 Jan 19;8(1). pii: E25. doi: 10.3390/v8010025.

 

TRANS PROF DB: A new resource for sharing translational profiles.

Spriggs RV, Willis AE.

Translation (Austin). 2014 Oct 30;2(2):e965615. doi: 10.4161/2169074X.2014.965615. eCollection 2014.

 

Glycogen synthase kinase-3 inhibition enhances translation of pluripotency-associated transcription factors to contribute to maintenance of mouse embryonic stem cell self-renewal.

Sanchez-Ripoll Y, Bone HK, Owen T, Guedes AM, Abranches E, Kumpfmueller B, Spriggs RV, Henrique D, Welham MJ.

PLoS One. 2013;8(4):e60148. doi: 10.1371/journal.pone.0060148.

Bioinformatics

Contact Details

MRC Toxicology Unit
Hodgkin Building
Lancaster Road, Leicester
LE1 7HB

Telephone and Email

+44 (0)116 252 5559

Affiliations

Classifications: