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MRC Toxicology Unit



Andy Smith has wide experience and collaboration in mechanistic toxicology and fundamental research with research interests that include genetics of haem and iron homeostasis/toxicity, the toxicity of pollutants such as dioxins and PCBs and gene expression in toxicity models. He has been a member of the government’s Committee of Toxicity as well as other committees and consultations and Chairman of the Royal Society of Chemistry’s Toxicology Group and President of the Environment, Sustainability and Energy Division.

to Present Director of Integrative Toxicology Training Partnership, MRC Toxicology Unit    

2001-2007  Programme leader, MRC Toxicology Unit
1993-2001  Section head, MRC Toxicology Unit, Leicester University
1977-1993  MRC Toxicology Unit, Carshalton, Surrey
1971-1977  Research Fellow, Chemistry and Forensic Medicine, Glasgow University
2000 DSc (Chemistry) Glasgow University
1971 PhD Liverpool University
1968 BSc (Biochemistry) Liverpool University



Key publications: 

CHERNOVA, T., STEINHERT, J.R., RICHARDS, P., MISTRY, R., CHALLISS, R.A.J., JUKES-JONES, R., CAIN, K., SMITH, A.G. and FORSYTHE, I.D. (2011) Early failure of N-methyl-D-aspartate receptors and deficient spine formation induced by reduction of regulatory heme in neurons. Molecular Pharmacology In press.

SMITH, A.G. (2010). Toxicology of DDT and some analogues. Handbook of Pesticide Toxicology 3rd edition (Ed. R I Krieger). 1975-2032. Academic Press.

SMITH, A.G. and ELDER, G.H. (2010) Complex gene-chemical interactions: hepatic uroporphyria as a paradigm. Chemical Research in Toxicology 23, 712-723.

KANNAN, M., STEINERT, J.R., FORSYTHE, I.D., SMITH, A.G., CHERNOVA, T. (2010) Mevastatin accelerates loss of synaptic proteins and neurite degeneration in aging cortical neurons in a heme-independent manner. Neurobiology of Aging 31, 1543-1553.

SMITH, A.G. and CHERNOVA, T. (2009) Disruption of heme synthesis by polyhalogenated aromatics. Advances in Molecular Toxicology 3, 161-210.

SMITH, A.G. AND NICOTERA, P. (2009) Injecting the future into toxicology. European Pharmaceutical Review Digital, Issue 2, 28-32.

CHERNOVA, T., HIGGINSON, F.M., DAVIES, R., SMITH, A.G. (2008) B2 SINE retrotransposon causes polymorphic expression of mouse 5-aminolevulinic acid synthase 1 gene. Biochemical and Biophysical Research Communications 377, 515-520.

GLEN, C.D., SMITH, A.G. and DUBROVA. Single-molecule PCR analysis of germ line mutation induction by anticancer drugs in mice. (2008) Cancer Research 68, 3630-3636.

DAVIES, R., CLOTHIER, B., ROBINSON, S.W., EDWARDS, R.E., GREAVES, P., LUO, J., GANT, T.W., CHERNOVA, T., and SMITH A.G. (2008) Essential role of the AH receptor in the dysfunction of heme metabolism by 2,3,7,8-tetrachloro-dibenzo-p-dioxin. Chemical Research in Toxicology 21, 330-340.

SMITH, A.G., HANSSON, M., RODRIGUEZ-PICHARDO A., FERRER-DUFOL. A., NEUBERT, R.T., WEBB, J.R., RAPPE, C., NEUBERT, D. (2008). Polychlorinated dibenzo-p-dioxins and the human immune system: 4. Studies on two Spanish families with increased body burdens of highly chlorinated PCDDs. Environment International 34, 330-344.

CHERNOVA, T., STEINERT, J.R., GUERIN, C.J. NICOTERA, P., FORSYTHE, I.D. and SMITH, A.G. (2007). Neurite degeneration induced by heme deficiency mediated via inhibition of NMDA receptor-dependent extracellular signal-regulated kinase 1/2 activation. Journal of Neuroscience 27, 8475-8485.

CHERNOVA, T., NICOTERA, P. And SMITH, A. G. (2006). Heme deficiency is associated with senescence and causes suppression of NMDA receptor subunits expression in primary cortical neurons. Molecular Pharmacology 69, 697-705.

GRANT, G.R., ROBINSON, S.W., EDWARDS, R.E., CLOTHIER, B., JUDAH, D.J., BROMAN, K.W. and SMITH, A.G. (2006) Multiple polymorphic loci determine basal hepatic and splenic iron status in mice. Hepatology 44, 174-185.

LIM, C.K., DANTON. M., CLOTHIER, B. and SMITH, A.G. (2006) Dihydroxy-, hydroxyspirolactone-, and dihydroxyspirolactone-urochlorins induced by 2,3,7,8-tetrachloro-p-dioxin in the liver of mice. Chemical Research in Toxicology 19, 1660-1667.

RIDD, K., ZHANG, S., EDWARDS, R.E., DAVIES, R., GREAVES, P., WOLFREYS, A., SMITH, A.G. and GANT, T.W. (2006) Association of gene expression with sequential proliferation, differentiation and tumor formation in murine skin. Carcinogenesis 27, 1556-1566.

Director of Integrative Toxicology Training Partnership

Contact Details

MRC Toxicology Unit
Hodgkin Building
Lancaster Road, Leicester

Telephone and Email

+44 (0)116 252 5617