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Mitochondria and cell death regulation following toxic injury

Dr L. Miguel Martins

We are investigating the cellular and molecular mechanisms that mitochondria use, as signaling hubs, for coping with toxic insults.  

 

We are a cell biology-based programme that aims to provide detailed, applicable, mechanistic toxicology, to identify the molecular initiating events and downstream toxicity pathways, associated with mitochondrial damage, that are disease relevant. To achieve our goals, we combine a series of approaches, including data analysis using computational tools, cultured cells and Drosophila as an in vivo model system.

We have diverse range of experitise, including genetics, computational biology, biochemistry and cell culture. This enables students to pursue multidisciplinary research.

We are open to applications for PhD studentships with our team. You can find-out more here.

 

Key publications

Fedele G, Loh SHY, Celardo I, Santos Leal N, Lehmann S, Costa AC and Martins LM. Suppression of intestinal dysfunction in a Drosophila model of Parkinson's disease is neuroprotective. Nature Aging, 2, 317-331. (2022).

Santos Leal N, Yu Y, Chen Y, Fedel G and Martins LM. Paracetemol is associated with a lower risk of COVID-19 infection and decreased ACE2 protein expression: a retrospective analysis. COVID1(1), 218-229. (2021).

Yu Y, Fedele G, Celardo I, Loh SHY and Martins LM. Parp mutations protect from mitochondrial toxicity in Alzheimer's disease. Cell Death Dis; 12(7):651. (2021).

Popovic R, Celardo I, Yu Y, Costa AC, Loh SHY and Martins LM. Combined transcriptomic and proteomic analysis of Perk toxicity pathways. Int J Mol Sci; 22(9):4598. (2021).

Santos Leal N and Martins LM. Mind the gap: mitochondria and the endoplasmic reticulum in neurodegenerative diseases. Biomedicines; 23(9):227. (2021).

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Video abstracts