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Unit Programme:  Mitochondria and cell death regulation following toxic injury

Dr L. Miguel Martins

Our aim is understanding the cellular and molecular mechanisms that mitochondria use, as signaling hubs, for coping with toxic insults.  We intend to manipulate these signaling mechanisms to protect tissues such as heart, liver and the brain from toxicity following exposure and in disease conditions.  This is a programme combining both dry and wet lab tools that aims to provide detailed, applicable, mechanistic toxicology, to identify the molecular initiating events and downstream toxicity pathways, associated with loss of mitochondrial function, that are disease relevant.

We have diverse range of experitise, including genetics, computational biology, biochemistry and cell culture. This enables students to pursue multidisciplinary research

Key Publications

Santos Leal et al.Paracetamol Is Associated with a Lower Risk of COVID-19 Infection and Decreased ACE2 Protein Expression: A Retrospective Analysis. COVID (2021)

 

Yu, Y. et al. Parp mutations protect from mitochondrial toxicity in Alzheimer's disease, Cell Death and Disease (2021)

 

Popovic, R. et al.  Combined transcriptomic and proteomic analysis of Perk toxicity pathways, International Journal of Molecular Sciences (2021)

 

Leal and Martins. Mind the Gap: Mitochondria and the Endoplasmic Reticulum in Neurodegenerative Diseases, Review, biomedicines (2021)

Article has an altmetric score of 2

Fedele, G. et al. Gut-brain axis neurodegeneration in a Drosophila model of Parkinson’s disease is linked to mitochondrial dysfunction, Research Square (2021)

Article has an altmetric score of 2

Yu, Y. et al. Alzheimer′s and Parkinson′s diseases predict different COVID-19 outcomes, a UK Biobank study, Geriatrics (2021)

Article has an altmetric score of 2

Travaglio, M. et al. Links between air pollution and COVID-19 in England, Environmental Pollution (2021).Video abstract here.

Article has an altmetric score of 2

Garrido-Maraver, J. et al. Forcing contacts between mitochondria and the endoplasmic reticulum extends lifespan in a Drosophila model of Alzheimer's disease, Biology Open (2020). Video abstract here.

Article has an altmetric score of 2

Garrido-Maraver, J. et al. Enhancing folic acid metabolism suppresses defects associated with loss of Drosophila mitofusin, Cell Death and Disease (2019). Video abstract here.

Article has an altmetric score of 2

Rakhit, CP. et al. Early detection of pre-malignant lesions in a KRASG12D-driven mouse lung cancer model by monitoring circulating free DNA, Disease Models and Mechanisms (2019). Video abstract here.

Article has an altmetric score of 2

Lehmann, S. et al. Folinic acid is neuroprotective in a fly model of Parkinson’s disease associated with pink1 mutations, matters (2017)

Article has an altmetric score of 2

Celardo, I. et al. dATF4 regulation of mitochondrial folate-mediated one-carbon metabolism is neuroprotective, Cell Death and Differentiation (2017). Video abstract here.

Article has an altmetric score of 91

Lehmann, S. et al. Enhancing NAD+ salvage metabolism is neuroprotective in a PINK1 model of Parkinson’s disease. Biology Open (2016)

Article has an altmetric score of 117

Sood, P. et al. Paraquat-induced metabolic stress signature in human foetal mesencephalic cells. matters (2016)

Article has an altmetric score of 2

Celardo, I. et al. Mitofusin-mediated ER stress triggers neurodegeneration in pink1/parkin models of Parkinson’s disease, Cell Death and Disease (2016). Video abstract here.

Article has an altmetric score of 106

Lehmann, S. et al. Parp mutations protect against mitochondrial dysfunction and neurodegeneration in a PARKIN model of Parkinson’s disease. Cell Death and Disease (2016)

Article has an altmetric score of 18

Bartesaghi, S. et al. Inhibition of oxidative metabolism leads to p53 genetic inactivation and transformation in neural stem cells. PNAS (2015)

Article has an altmetric score of 20

Andree, M. et al. BID-dependent release of mitochondrial SMAC dampens XIAP-mediated immunity against Shigella. The EMBO Journal (2014)

Article has an altmetric score of 10

Requejo-Aguilar, R. et al. PINK1 deficiency sustains cell proliferation by reprogramming glucose metabolism through HIF1. Nature Communications 5, 1–9 (2014)

Article has an altmetric score of 17

Tufi, R. et al. Enhancing nucleotide metabolism protects against mitochondrial dysfunction and neurodegeneration in a PINK1 model of Parkinson’s disease. Nature Cell Biology  (2014)

Article has an altmetric score of 21

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