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MRC Toxicology Unit

 

Unit Programme:  Mitochondria and cell death regulation following toxic injury

Programme Leader: Dr L. Miguel Martins

 

The aim of Miguel’s research programme is understanding the cellular and molecular mechanisms that mitochondria use, as signaling hubs, for coping with toxic insults.  We aim to manipulate these signaling mechanisms to protect tissues such as heart, liver and the brain from toxicity following exposure and in disease conditions.  Thus, this is a cell biology-based programme that aims to provide detailed, applicable, mechanistic toxicology, to identify the molecular initiating events and downstream toxicity pathways, associated with loss of mitochondrial function, that are disease relevant.

 

Key Publications

Garrido-Maraver, J. et al. Enhancing folic acid metabolism suppresses defects associated with loss of Drosophila mitofusin, Cell Death and Disease (2019)

Rakhit, CP. et al. Early detection of pre-malignant lesions in a KRASG12D-driven mouse lung cancer model by monitoring circulating free DNA, Disease Models and Mechanisms (2019)

 

Lehmann, S. et al. Folinic acid is neuroprotective in a fly model of Parkinson’s disease associated with pink1 mutations, matters (2017)

Article has an altmetric score of 2

Celardo, I. et al. dATF4 regulation of mitochondrial folate-mediated one-carbon metabolism is neuroprotective, Cell Death and Differentiation (2017)

Article has an altmetric score of 91

Lehmann, S. et al. Enhancing NAD+ salvage metabolism is neuroprotective in a PINK1 model of Parkinson’s disease. Biology Open (2016)

Article has an altmetric score of 117

Sood, P. et al. Paraquat-induced metabolic stress signature in human foetal mesencephalic cells. matters (2016)

Article has an altmetric score of 2

Celardo, I. et al. Mitofusin-mediated ER stress triggers neurodegeneration in pink1/parkin models of Parkinson’s disease, Cell Death and Disease (2016)

Article has an altmetric score of 106

Lehmann, S. et al. Parp mutations protect against mitochondrial dysfunction and neurodegeneration in a PARKIN model of Parkinson’s disease. Cell Death and Disease (2016)

Article has an altmetric score of 18

Bartesaghi, S. et al. Inhibition of oxidative metabolism leads to p53 genetic inactivation and transformation in neural stem cells. PNAS (2015)

Article has an altmetric score of 20

Andree, M. et al. BID-dependent release of mitochondrial SMAC dampens XIAP-mediated immunity against Shigella. The EMBO Journal (2014)

Article has an altmetric score of 10

Requejo-Aguilar, R. et al. PINK1 deficiency sustains cell proliferation by reprogramming glucose metabolism through HIF1. Nature Communications 5, 1–9 (2014)

Article has an altmetric score of 17

Tufi, R. et al. Enhancing nucleotide metabolism protects against mitochondrial dysfunction and neurodegeneration in a PINK1 model of Parkinson’s disease. Nature Cell Biology  (2014)

Article has an altmetric score of 21